CAS 1217769-52-2 Diltiazem-[d4] Hydrochloride

General Information
Catalog: BLP-006062
CAS: 1217769-52-2
Molecular Formula: C22H23D4ClN2O4S
Molecular Weight: 455.00

General Information

Catalog: BLP-006062

CAS: 1217769-52-2

Molecular Formula: C22H23D4ClN2O4S

Molecular Weight: 455.00

Chemical Structure

Catalog Number	Size	Price	Stock	Quantity
BLP-006062	1 mg	$699	In stock

Catalog Number

Size

Price

Stock

Quantity

BLP-006062

1 mg

$699

In stock

Description	Diltiazem-[d4] Hydrochloride is a deuterium labelled form of Diltiazem. Diltiazem is a calcium channel blocker medication used to treat high blood pressure, angina, and certain heart arrhythmias.
Synonyms	(2S,cis)-3-(Acetyloxy)-5-[(2-dimethylamino-d4)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Hydrochloride; Diltiazem d4 HCl
IUPAC Name	[(2S,3S)-2-(4-methoxyphenyl)-4-oxo-5-[1,1,2,2-tetradeuterio-2-(dimethylamino)ethyl]-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate;hydrochloride
Related CAS	112259-41-3 (free base) 33286-22-5 (unlabelled)
Canonical SMILES	CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl
InChI	InChI=1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1/i13D2,14D2;
InChI Key	HDRXZJPWHTXQRI-DJWNGNTESA-N
Melting Point	>192°C (dec.)
Purity	98% by CP; 98% atom D
Solubility	Soluble in DMSO, Methanol
Appearance	Off-white to Pale Yellow Solid
Storage	Store at-20°C, Under inert atmosphere

Diltiazem-[d4] Hydrochloride is a deuterated form of the calcium channel blocker diltiazem, commonly used in research. Here are some key applications of Diltiazem-[d4] Hydrochloride:

Pharmacokinetic Studies: Diltiazem-[d4] Hydrochloride is employed in pharmacokinetic studies to understand the absorption, distribution, metabolism, and excretion of diltiazem. The deuterium-labeled compound allows for precise tracking using mass spectrometry. This helps in providing detailed insights into the drug’s behavior within the body.

Drug Metabolism Research: Researchers use Diltiazem-[d4] Hydrochloride to study the metabolic pathways of diltiazem. By comparing the metabolism of the deuterated and non-deuterated forms, scientists can identify key metabolites and enzymes involved in the drug’s biotransformation. This information is crucial for optimizing drug formulations and identifying potential drug-drug interactions.

Receptor Binding Studies: In receptor binding assays, Diltiazem-[d4] Hydrochloride can be used to study the interaction between diltiazem and calcium channels. Its deuterated nature allows for differentiation from endogenous compounds, providing more accurate data. These studies are essential for understanding the drug’s mechanism of action and improving its therapeutic efficacy.

Cardiovascular Research: Diltiazem-[d4] Hydrochloride is utilized in cardiovascular research to investigate its effects on heart function and blood pressure regulation. By using this deuterated analog, researchers can conduct detailed studies on drug efficacy and safety in various cardiac conditions. This aids in the development of improved therapeutic strategies for cardiovascular diseases.