Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-009755 |
CAS: 1242074-21-0 |
Molecular Formula: C2[13C]H6DNO2 |
Molecular Weight: 91.09 |
Chemical Structure |
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Description | DL-alanine-[1-13C,2-d] is a labelled DL-alanine. Alanine is one of the non-essential amino acids for humans. Alanine is the key compound in glucose-alanine cycle. |
IUPAC Name | 2-amino-2-deuterio(1-13C)propanoic acid |
Related CAS | 302-72-7 (unlabelled) |
Canonical SMILES | CC(C(=O)O)N |
InChI | InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/i2D,3+1 |
InChI Key | QNAYBMKLOCPYGJ-BCBQPROLSA-N |
Melting Point | 289°C (dec.)(lit.) |
Purity | 95% by HPLC; 98% atom D, 99% atom 13C |
DL-Alanine-[1-13C,2-d], an isotopically labeled amino acid, finds diverse applications in scientific and industrial realms. Here are key applications of DL-Alanine-[1-13C,2-d] presented with high perplexity and burstiness:
Metabolic Tracing: DL-Alanine-[1-13C,2-d] serves as a metabolic tracer in biochemical investigations, shedding light on amino acid metabolism and turnover dynamics within organisms. By tracing the journey of labeled carbon isotopes, researchers unveil the intricate metabolic pathways of alanine, illuminating its pivotal roles in cellular energy generation and biosynthesis. This knowledge is paramount in unraveling metabolic anomalies and formulating effective therapeutic strategies.
Nuclear Magnetic Resonance (NMR) Studies: Widely employed in NMR spectroscopy, DL-Alanine-[1-13C,2-d] plays a critical role in probing protein structures and dynamics. The isotopic labeling boosts the resolution and sensitivity of NMR signals, empowering researchers to glean profound insights into protein folding mechanisms and interactions. This application stands as a cornerstone in drug discovery endeavors and dissecting the molecular underpinnings of diseases.
Stable Isotope-Labeling Experiments: Within life sciences research, DL-Alanine-[1-13C,2-d] emerges as a stable isotope label for experiments investigating amino acid incorporation into proteins. This technique aids in quantifying protein synthesis and degradation rates across various biological systems, offering invaluable insights into cellular processes such as growth, development, and responses to environmental cues. Such studies play a pivotal role in advancing our understanding of complex biological phenomena.
Mass Spectrometry Analysis: DL-Alanine-[1-13C,2-d] finds utility in mass spectrometry analyses, enabling precise quantification of metabolic processes and profiling of metabolite distributions. The presence of labeled isotopes facilitates accurate mass distinctions, enhancing the identification and quantification of alanine and its metabolites in intricate biological samples. This analytical approach is instrumental in conducting comprehensive metabolic profiling and spearheading biomarker discovery initiatives in both research and clinical diagnostics arenas.
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