DL-Serine-[2-13C]

DL-Serine-[2-13C] is an isotopically labeled amino acid used in various research applications. Here are some key applications of DL-Serine-[2-13C]:

Metabolic Flux Analysis: DL-Serine-[2-13C] is used in metabolic flux analysis studies to trace metabolic pathways within cells. By incorporating this labeled compound, researchers can track the flow of carbon atoms through various biochemical reactions. This helps in understanding cellular metabolism and identifying key regulatory nodes.

NMR Spectroscopy: In NMR spectroscopy, DL-Serine-[2-13C] serves as a tracer to study the structure and dynamics of proteins and other biomolecules. The isotopic labeling enhances signal detection, allowing for detailed analysis of molecular interactions and conformations. This tool is invaluable in structural biology and drug design.

Proteomics: DL-Serine-[2-13C] is utilized in proteomics to quantify protein turnover and synthesis rates within cells. By incorporating the labeled serine into newly synthesized proteins, mass spectrometry can be used to measure protein synthesis dynamics. This information is crucial for understanding cellular responses to various conditions and treatments.

Brain Function Studies: DL-Serine-[2-13C] is employed in neuroscience research to investigate serine metabolism in brain function and neurochemistry. The labeled compound helps in studying the role of serine in neurotransmitter synthesis and neuronal signaling pathways. This research is important for understanding neurological disorders and developing therapeutic strategies.