Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-008138 |
Molecular Formula: C2[13C]H7NO3 |
Molecular Weight: 106.09 |
Chemical Structure |
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Description | DL-Serine-[3-13C] is a labelled DL-Serine. Serine is an α-amino acid used in the biosynthesis of proteins. |
Synonyms | DL-Serine-3-13C; 2-amino-3-hydroxypropanoic acid-13C |
IUPAC Name | 2-amino-3-hydroxy(3-13C)propanoic acid |
Related CAS | 302-84-1 (unlabelled) |
Canonical SMILES | C(C(C(=O)O)N)O |
InChI | InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/i1+1 |
InChI Key | MTCFGRXMJLQNBG-OUBTZVSYSA-N |
Purity | 98% by CP; 99% atom 13C |
Storage | Store at -20°C |
DL-Serine-[3-13C], a labeled amino acid with diverse applications in bioscience, is a valuable tool in metabolic and molecular studies. Here are the key applications of DL-Serine-[3-13C]:
Metabolic Flux Analysis: Utilizing DL-Serine-[3-13C] in metabolic flux analysis enables researchers to map out metabolic pathways and trace the movement of carbon atoms across different biochemical reactions. By introducing this labeled amino acid into cell cultures, scientists can track isotope integration using advanced techniques like mass spectrometry or NMR spectroscopy. This methodology helps unveil the dynamics of pathways and the regulatory networks governing metabolism.
Stable Isotope Labeling: DL-Serine-[3-13C] serves as a crucial component in stable isotope labeling for proteomics and metabolomics inquiries. When incorporated into organisms or cell cultures, this amino acid allows researchers to monitor protein turnover rates and metabolic transformations. Such investigations offer valuable insights into protein synthesis, degradation kinetics, and metabolic adjustments under diverse environmental stimuli, shedding light on cellular responses.
Structural Biology: In the realm of structural biology, DL-Serine-[3-13C] finds application in NMR spectroscopy for elucidating protein structures and dynamics. By embedding the labeled serine at specific sites within proteins, scientists gain intricate insights into local environments and molecular interactions. This detailed information aids in unraveling the intricacies of protein folding, functionality, and intermolecular associations at the atomic scale, providing a deeper understanding of biological mechanisms.
Enzyme Mechanism Studies: DL-Serine-[3-13C] is a pivotal tool for investigating enzyme mechanisms, especially those involving serine as a catalytic component or substrate. By leveraging this labeled form, researchers can scrutinize shifts in isotopic distribution during enzyme-driven reactions. This approach allows for the exploration of catalytic pathways, transition states, and enzyme-substrate interactions, offering profound insights into the fundamental processes that drive biochemical reactions.
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