Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-007395 |
CAS: 91679-34-4 |
Molecular Formula: C8[13C]H11NO3 |
Molecular Weight: 182.2 |
Chemical Structure |
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Description | DL-Tyrosine-[1-13C] is a labelled DL-Tyrosine. Tyrosine is a non-essential amino acid synthesized from phenylalanine. It is the precursor of some neurotransmitters. |
Synonyms | DL-4-Hydroxyphenyl(alanine-1-13C); DL-tyrosine 1-13C |
IUPAC Name | 2-amino-3-(4-hydroxyphenyl)(1-13C)propanoic acid |
Related CAS | 556-03-6 (unlabelled) |
Isomeric SMILES | C1=CC(=CC=C1CC([13C](=O)O)N)O |
Canonical SMILES | C1=CC(=CC=C1CC(C(=O)O)N)O |
InChI | InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/i9+1 |
InChI Key | OUYCCCASQSFEME-QBZHADDCSA-N |
Melting Point | >300°C (dec.) (lit.) |
Purity | 98% by HPLC; 99% atom 13C |
Storage | Store at -20°C |
DL-Tyrosine-[1-13C], an isotopically labeled amino acid with manifold scientific applications, particularly shines in metabolic and biochemical research. Here are the key applications of DL-Tyrosine-[1-13C]:
Metabolic Pathway Tracing: Employing DL-Tyrosine-[1-13C], researchers delve into metabolic pathways, unveiling the destiny of tyrosine in diverse biochemical processes. By introducing this labeled amino acid into cells or organisms, scientists meticulously monitor its metabolic transformation using cutting-edge NMR or mass spectrometry techniques. This intricate process aids in unraveling complex metabolic networks and pinpointing metabolic bottlenecks or inefficiencies, shedding light on the intricate dance of molecules within living systems.
Protein Synthesis Studies: In the realm of protein synthesis research, DL-Tyrosine-[1-13C] serves as a powerful tool for investigating the incorporation of tyrosine into proteins. By tracing the labeled tyrosine, scientists scrutinize the dynamics of protein synthesis, degradation, and turnover across various biological systems. This invaluable data is pivotal for unraveling the intricate ballet of proteins within cells and for formulating innovative strategies for mitigating diseases at the molecular level.
Neurotransmitter Research: Delving into the world of neurotransmitters like dopamine and norepinephrine, which originate from tyrosine, DL-Tyrosine-[1-13C] emerges as a crucial asset. Researchers harness this labeled compound to probe the intricate pathways of neurotransmitter biosynthesis, regulation, and degradation within neuronal tissues. This deep understanding of neurotransmitter dynamics is fundamental for unraveling the mysteries of neurological disorders and for crafting novel therapies for conditions such as Parkinson’s disease and depression, illuminating the complex interplay of chemicals in the brain.
Nutritional Studies: Within the domain of nutrition, DL-Tyrosine-[1-13C] plays a vital role in scrutinizing the absorption, metabolism, and utilization of tyrosine within the human body. By administering this isotopically labeled amino acid, researchers track its metabolic journey and assess the repercussions of various dietary interventions with precision. This meticulous examination not only informs the formulation of evidence-based nutritional guidelines but also unveils the intricate role of tyrosine in maintaining health and combating disease, providing a nuanced understanding of the interplay between diet and metabolism.
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