DL-Valine-[15N]

DL-Valine-[15N] is an isotopically labeled amino acid used in various scientific and industrial applications. Here are some key applications of DL-Valine-[15N]:

Protein Structure Analysis: DL-Valine-[15N] is essential in nuclear magnetic resonance (NMR) spectroscopy for studying protein structures. By incorporating this labeled amino acid into proteins, researchers can gain insights into protein folding dynamics and interactions. This information is crucial for understanding protein function and identifying potential drug targets.

Metabolic Flux Analysis: In metabolic research, DL-Valine-[15N] is employed to trace nitrogen flow through metabolic pathways. By tracking the incorporation of the labeled nitrogen, scientists can analyze metabolic fluxes in cells and organisms. This application is particularly useful for optimizing microbial fermentation processes and developing biotechnological applications.

Nutritional Biochemistry: DL-Valine-[15N] is used to study amino acid metabolism and nitrogen balance in nutritional science. Researchers can investigate the utilization and turnover of valine in different physiological states such as growth, exercise, or disease. This helps in formulating dietary recommendations and understanding the metabolic impacts of various diets.

Drug Metabolism Studies: In pharmacokinetics and drug metabolism research, DL-Valine-[15N] serves as a tracer to study the metabolic pathways and biotransformation of drugs. By following the labeled amino acid, researchers can identify metabolites and assess the pharmacokinetic profiles of therapeutic compounds. This application aids in the development of safer and more effective drugs.