Doxazosin-[13C4]

General Information
Catalog: BLP-000884
Molecular Formula: C19[13C]4H25N5O5
Molecular Weight: 455.45
Related CAS: 74191-85-8 (unlabelled)
Description Doxazosin-[13C4] is the labelled analogue of Doxazosin. Doxazosin is a quinazoline-derivative and long-lasting α1 adrenergic receptor blocker. It inhibits the binding of norepinephrine, which is released from sympathetic nerve terminals, to the α-1 receptors on the membrane of vascular smooth muscle cells. It is widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms. It may have an inhibitory effect on cholesterol synthesis independent of the LDL receptor.
Synonyms [13C4]-Doxazosin; [13C4]-racemic mixture Doxazosin; [13C4]-UK 33274
IUPAC Name [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-(2,3,5,6-13C4)1,4-diazinan-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone
Canonical SMILES COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
InChI InChI=1S/C23H25N5O5/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26)/i7+1,8+1,9+1,10+1
InChI Key RUZYUOTYCVRMRZ-HZKSPUCSSA-N

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