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Doxofylline-[d6]

General Information
Catalog: BLP-012329
CAS: 1219805-99-8
Molecular Formula: C11H8D6N4O4
Molecular Weight: 272.29
Chemical Structure
Doxofylline-[d6]
Description Doxofylline-[d6] is an isotope labelled doxofylline. Doxofylline is a xanthine derivative drug used to treat asthma.
Synonyms Doxofylline D6; 7-(1,3-Dioxolan-2-ylmethyl)-1,3-bis[(2H3)methyl]-3,7-dihydro-1H-purine-2,6-dione
Related CAS 69975-86-6 (unlabelled)
Canonical SMILES CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC3OCCO3
InChI InChI=1S/C11H14N4O4/c1-13-9-8(10(16)14(2)11(13)17)15(6-12-9)5-7-18-3-4-19-7/h6-7H,3-5H2,1-2H3/i1D3,2D3
InChI Key HWXIGFIVGWUZAO-WFGJKAKNSA-N
Purity 95%+ by HPLC; 98% atom D
Storage Store at -20°C

Doxofylline-[d6] is a steroid-labeled compound with diverse applications in research and clinical settings. Here are the key applications of Doxofylline-[d6]:

Pharmacokinetic Studies: Doxofylline-[d6] plays a pivotal role in pharmacokinetic investigations, providing insights into the drug's absorption, distribution, metabolism, and excretion dynamics. The deuterated form enables precise tracking through advanced mass spectrometry techniques. Researchers delve into the intricate behavior of the drug within the body, a critical aspect in fine-tuning dosages for enhanced therapeutic outcomes.

Metabolism Research: In the realm of metabolism exploration, Doxofylline-[d6] serves as a valuable tool for unraveling the complex metabolic pathways and enzymatic processes governing the biotransformation of the drug. Through the study of the labeled molecule, scientists can pinpoint metabolites and decipher the underlying mechanisms of drug metabolism. This knowledge is indispensable for evaluating the safety and efficacy profiles of pharmaceutical agents.

Bioavailability Studies: Doxofylline-[d6] aids in elucidating the bioavailability of drugs by comparing the deuterated variant with its non-labeled counterpart. Researchers quantitatively assess the drug's entry into systemic circulation, shedding light on absorption kinetics. Such studies are pivotal in designing formulations that optimize drug absorption rates and therapeutic efficacy, contributing to improved patient outcomes.

Drug Interaction Analysis: By leveraging Doxofylline-[d6], researchers delve into the realm of drug-drug interactions during preclinical evaluations. Through observations of the interplay between the deuterated compound and co-administered drugs, scientists anticipate potential interactions and recommend dosage adjustments. This application is instrumental in safeguarding patient well-being amidst complex polypharmacy scenarios, ensuring the safety and efficacy of medication regimens.

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