Drospirenone-[d4] - Isotope / BOC Sciences

General Information
Catalog: BLP-012330
Molecular Formula: C24H26D4O3
Molecular Weight: 370.52

General Information

Catalog: BLP-012330

Molecular Formula: C24H26D4O3

Molecular Weight: 370.52

Chemical Structure

Description	Drospirenone-[d4] is an isotope labelled Drospirenone. Drospirenone can be used in birth control pills and postmenopausal hormone replacement therapy pills. It is a synthetic progestogen exhibiting antimineralocorticoid and antiandrogenic activity.
Synonyms	Drospirenone D4
IUPAC Name	(1R,2R,4R,10R,11S,14S,15S,16S,18S,19S)-3',3',8,8-tetradeuterio-10,14-dimethylspiro[hexacyclo[9.8.0.02,4.05,10.014,19.016,18]nonadec-5-ene-15,5'-oxolane]-2',7-dione
Related CAS	67392-87-4 (unlabelled)
Canonical SMILES	[2H]C1(C[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3[C@H]5C[C@H]5C2=CC1=O)[C@@H]6C[C@@H]6[C@@]47CC(C(=O)O7)([2H])[2H])C)C)[2H]
InChI	InChI=1S/C24H30O3/c1-22-6-3-12(25)9-17(22)13-10-14(13)20-16(22)4-7-23(2)21(20)15-11-18(15)24(23)8-5-19(26)27-24/h9,13-16,18,20-21H,3-8,10-11H2,1-2H3/t13-,14+,15-,16+,18+,20-,21+,22-,23+,24+/m1/s1/i3D2,5D2
InChI Key	METQSPRSQINEEU-AJJTXNBQSA-N
Purity	98% by HPLC; 96% atom D
Storage	Store at -20°C

Drospirenone-[d4], a deuterated iteration of the synthetic hormone drospirenone, plays a pivotal role in various scientific research endeavors. Here are the key applications of Drospirenone-[d4]:

Pharmacokinetic Studies: Immersing into the intricate realm of pharmacokinetics with Drospirenone-[d4] unveils profound insights into drug absorption, distribution, metabolism, and excretion. Acting as an internal standard in mass spectrometry, this deuterated compound simplifies precise quantification and comparison of pharmacokinetic profiles. Such studies serve as foundational pillars in unraveling the labyrinthine behaviors of the drug within the human body and refining dosing strategies for optimal therapeutic outcomes.

Drug Interaction Analysis: Within the realm of scrutinizing drug interactions, Drospirenone-[d4] shines as a guiding beacon elucidating the complex interplay between drospirenone and other pharmaceutical agents. By utilizing the deuterated variant, researchers can differentiate between the target drug and potential metabolites or co-administered drugs, paving the way for assessing the safety and efficacy of combination therapies. This differentiation acts as a robust defense against adverse drug interactions, optimizing treatment regimens for maximal efficacy.

Metabolic Pathway Elucidation: Harnessing the power of Drospirenone-[d4], scientists embark on a journey to unravel the intricate metabolic pathways of drospirenone both in controlled laboratory settings and within living organisms. Leveraging stable isotope labeling, researchers conduct detailed scrutiny of metabolites through advanced analytical methodologies like LC-MSMS. This wealth of knowledge helps in identifying active metabolites and deciphering the complex mechanisms through which the drug exerts its pharmacological effects.

Bioequivalence Studies: In the realm of evaluating bioequivalence, Drospirenone-[d4] emerges as a crucial tool for comparing the pharmacokinetic profiles of generic and branded formulations of drospirenone-containing medications. Serving as a reliable marker, the deuterated compound ensures that the generic product aligns with its branded counterpart in terms of absorption and bioavailability. Such studies act as cornerstones for securing regulatory approvals and navigating the competitive landscape of generic pharmaceuticals.