CAS 1092484-56-4 Fenofibrate-[d6] - Isotope / BOC Sciences

General Information
Catalog: BLP-012356
CAS: 1092484-56-4
Molecular Formula: C20H15D6ClO4
Molecular Weight: 366.87

General Information

Catalog: BLP-012356

CAS: 1092484-56-4

Molecular Formula: C20H15D6ClO4

Molecular Weight: 366.87

Chemical Structure

Description	Fenofibrate-[d6] is a labelled form of Fenofibrate. Fenofibrate (Tricor, Trilipix) is a compound of the fibrate class and fibric acid derivative. It is used alone or along with statins in the treatment of hypercholesterolemia and hypertriglyceridemia.
Synonyms	Fenofibrate D6; 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methyl-propanoic Acid-d6 1-Methylethyl Ester; LF 178-d6; Lipanthyl-d6; Lipantil-d6; Lipidil Supra-d6; Lipirex-d6; Lipoclar-d6; Lipofene-d6; Liposit-d6; Lipsin-d6; MeltDose-d6; NSC 281319-d6; Nolipax-d6
IUPAC Name	propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-3,3,3-trideuterio-2-(trideuteriomethyl)propanoate
Related CAS	49562-28-9 (unlabelled)
Isomeric SMILES	[2H]C([2H])([2H])C(C(=O)OC(C)C)(C([2H])([2H])[2H])OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl
Canonical SMILES	CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl
InChI	InChI=1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3/i3D3,4D3
InChI Key	YMTINGFKWWXKFG-LIJFRPJRSA-N
Boiling Point	469.8±35.0 °C at 760 mmHg
Melting Point	70-72°C
Purity	98% by HPLC; 99% atom D
Density	1.2±0.1 g/cm3
Solubility	Soluble in Chloroform, Methanol
Appearance	White to Off-white Solid
Storage	Store at -20°C

Fenofibrate-[d6], an isotopically labeled variant of fenofibrate commonly utilized in research environments, offers a myriad of applications. Here are the key applications of Fenofibrate-[d6]:

Pharmacokinetic Studies: Widely employed in pharmacokinetic investigations, Fenofibrate-[d6] facilitates the tracing of fenofibrate's absorption, distribution, metabolism, and excretion (ADME) within biological systems. Its isotopic label enables precise tracking through mass spectrometry, crucial for unraveling the drug's bioavailability and optimizing dosing protocols.

Metabolite Identification: Researchers harness Fenofibrate-[d6] to identify and quantify fenofibrate metabolites in plasma, urine, and other biological specimens. The stable isotope label aids in distinguishing the parent drug from its metabolites even at minimal concentrations. This application plays a pivotal role in elucidating metabolic pathways and potential drug interactions.

Bioanalytical Method Development: Serving as an internal standard in bioanalytical method development and validation, Fenofibrate-[d6] ensures accuracy and consistency in quantifying fenofibrate levels across diverse biological matrices. This role is particularly critical in clinical trials and therapeutic drug monitoring scenarios.

Mechanistic Studies: By utilizing Fenofibrate-[d6], researchers can delve into the molecular mechanisms underlying the action of fenofibrate. Studies can illuminate how fenofibrate impacts lipid metabolism and interacts with peroxisome proliferator-activated receptors (PPARs). This in-depth understanding contributes to the formulation of more potent lipid-modifying therapeutic approaches.