CAS 1276197-21-7 Flecainide-[d4] acetate

General Information
Catalog: BLP-012360
CAS: 1276197-21-7
Molecular Formula: C19H20D4F6N2O5
Molecular Weight: 478.42

General Information

Catalog: BLP-012360

CAS: 1276197-21-7

Molecular Formula: C19H20D4F6N2O5

Molecular Weight: 478.42

Chemical Structure

Description	Flecainide-[d4] acetate is an isotope labelled Flecainide acetate. Flecainide acetate is an antiarrhythmic agent used to prevent and treat tachyarrhythmias.
Synonyms	Flecainide D4 acetate
IUPAC Name	acetic acid;2,5-bis(1,1-dideuterio-2,2,2-trifluoroethoxy)-N-(piperidin-2-ylmethyl)benzamide
Related CAS	54143-56-5 (unlabelled)
Canonical SMILES	CC(=O)O.C1CCNC(C1)CNC(=O)C2=C(C=CC(=C2)OCC(F)(F)F)OCC(F)(F)F
InChI	InChI=1S/C17H20F6N2O3.C2H4O2/c18-16(19,20)9-27-12-4-5-14(28-10-17(21,22)23)13(7-12)15(26)25-8-11-3-1-2-6-24-11;1-2(3)4/h4-5,7,11,24H,1-3,6,8-10H2,(H,25,26);1H3,(H,3,4)/i9D2,10D2;
InChI Key	RKXNZRPQSOPPRN-PQDNHERISA-N
Purity	95% by HPLC; 99% atom D
Storage	Store at -20°C

Flecainide-[d4] acetate is a deuterated form of flecainide which is commonly used in cardiology. Here are some key applications of Flecainide-[d4] acetate:

Pharmacokinetic Studies: Flecainide-[d4] acetate is used in pharmacokinetic studies to understand the absorption, distribution, metabolism, and excretion (ADME) of flecainide in the body. The deuterated version provides more accurate tracing in mass spectrometry, allowing researchers to monitor the drug's pathway with greater precision. This is critical in optimizing dosage and understanding drug interactions.

Drug Interaction Studies: Flecainide-[d4] acetate is employed in drug-drug interaction studies to understand how flecainide interacts with other medications. The use of the deuterated form allows for specific and sensitive detection in biological matrices. This information is crucial for developing safe co-administration protocols and avoiding adverse interactions.

Metabolic Stability Assessments: Flecainide-[d4] acetate helps in assessing the metabolic stability of flecainide in different biological systems. By tracing the labeled drug, researchers can study how it is metabolized and identify any potential metabolic liabilities. This assists in improving the formulation and increasing the drug's therapeutic efficacy.