Fmoc-L-Serine-[d3]

Fmoc-L-Serine-[d3] is a deuterated amino acid derivative used in various bioscience applications. Here are some key applications of Fmoc-L-Serine-[d3]:

Stable Isotope Labeling: Fmoc-L-Serine-[d3] is used in stable isotope labeling for mass spectrometry-based proteomics. The deuterium label allows for precise quantification and differentiation of peptides and proteins in complex mixtures. This aids in accurate protein identification and understanding of protein dynamics in biological systems.

Peptide Synthesis: This deuterated amino acid is incorporated into peptides during solid-phase peptide synthesis. The presence of deuterium helps researchers study peptide behavior, folding, and interaction dynamics. It also allows for the creation of labeled peptide standards used in various analytical applications.

Metabolic Flux Analysis: In metabolic studies, Fmoc-L-Serine-[d3] is employed to trace metabolic pathways and analyze the turnover rates of serine. The labeled serine can provide detailed information on serine metabolism and its role in cellular processes. This is crucial for understanding metabolic diseases and developing targeted metabolic interventions.

NMR Spectroscopy: Fmoc-L-Serine-[d3] is useful in nuclear magnetic resonance (NMR) spectroscopy to investigate the structure and dynamics of proteins and peptides. The deuterium label reduces signal overlap and enables clearer spectra. This facilitates the detailed study of molecular interactions and conformational changes.