Name: Gilteritinib-[d8]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-015086

CAS: 2377109-74-3

Molecular Formula: C29H36D8N8O3

Molecular Weight: 560.76

Chemical Structure

Description	Gilteritinib-[d8] is an isotope labelled Gilteritinib, a potent FLT3/AXL inhibitor used as an antineoplastic agent in the treatment of acute myeloid leukemia with FLT3 mutations.
Synonyms	6-Ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)piperidin-1-yl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide; Gilteritinib d8; 6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide-d8; ASP 2215-d8; Gilteritinib-d8
IUPAC Name	6-ethyl-3-[3-methoxy-4-[4-(2,2,3,3,5,5,6,6-octadeuterio-4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide
Related CAS	1254053-43-4 (unlabelled)
Canonical SMILES	[2H]C1(C(N(C(C(N1C)([2H])[2H])([2H])[2H])C2CCN(CC2)C3=C(C=C(C=C3)NC4=NC(=C(N=C4C(=O)N)CC)NC5CCOCC5)OC)([2H])[2H])[2H]
InChI	InChI=1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34)/i13D2,14D2,15D2,16D2
InChI Key	GYQYAJJFPNQOOW-DBVREXLBSA-N
Purity	>95%
Solubility	Soluble in DMSO, Ethanol
Appearance	White to yellow solid
Storage	Store at 2-8 °C