Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-007095 |
Molecular Formula: C8[13C]2H17N2[15N]O6S.CF3COOH |
Molecular Weight: 424.33 |
Chemical Structure |
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Description | Glutathione-[glycine-13C2,15N] Trifluoroacetate is the labelled derivative of Glutathione. Glutathione (GSH) is the most important nonprotein thiol widely distributed in animal tissues, plants, and microorganisms. |
Synonyms | Glutathione-(glycine-13C2,15N) trifluoroacetate salt; L-Glutamyl-L-cysteinyl-glycine-13C2,15N Trifluoroacetate Salt; H-gGlu-Cys-Gly-OH-13C2,15N TFA; L-Glutathione-13C2,15N Trifluoroacetate Salt; Glutathione-13C2,15N Trifluoroacetate Salt; L-gamma-glutamyl-L-cysteinylglycine-13C2,15N Trifluoroacetate Salt; Glutathione-SH-13C2,15N Trifluoroacetate Salt; GSH-13C2,15N Trifluoroacetate Salt |
IUPAC Name | (2S)-2-amino-5-[[(2R)-1-hydroxy-(((carboxy-13C)methyl-13C)amino-15N)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid;2,2,2-trifluoroacetic acid |
Related CAS | 70-18-8 (unlabelled free base) 815610-65-2 (free base) |
Canonical SMILES | C(CC(=O)NC(CS)C(=O)NCC(=O)O)C(C(=O)O)N.C(=O)(C(F)(F)F)O |
InChI | InChI=1S/C10H17N3O6S.C2HF3O2/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16;3-2(4,5)1(6)7/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19);(H,6,7)/t5-,6-;/m0./s1/i3+1,8+1,12+1; |
InChI Key | DUDRWKYPABUBBV-KFJNRMSPSA-N |
Purity | ≥95% by CP; ≥99% atom 13C; ≥98% atom 15N |
Solubility | Slightly soluble in Aqueous Base, Water |
Appearance | Off-white Solid |
Storage | Store at -20°C under inert atmosphere |
Glutathione-[13C2,15N] trifluoroacetate salt, a stable isotope-labeled compound, finds diverse applications in scientific and analytical realms. Here are key applications presented with high perplexity and burstiness:
Metabolomics: Within the domain of metabolomics, Glutathione-[13C2,15N] trifluoroacetate salt emerges as a pivotal tool, functioning as a labeled internal standard for precise quantification of glutathione levels in biological samples. This enables researchers to monitor fluctuations in antioxidant status and oxidative stress within cells and tissues, shedding light on metabolic shifts and pathological conditions.
Pharmacokinetics: Delving into the intricacies of drug metabolism, researchers harness Glutathione-[13C2,15N] trifluoroacetate salt in pharmacokinetic inquiries to trace the absorption, distribution, metabolism, and excretion of drugs and metabolites, particularly those involving glutathione conjugation. By unraveling the role of glutathione in drug metabolism and potential interactions, its application deepens insights into drug safety and efficacy profiles.
Proteomics: In the sphere of proteomics, labeled glutathione plays a crucial role in studying protein glutathionylation, a post-translational modification that influences protein functionality. By integrating Glutathione-[13C2,15N] into mass spectrometry workflows, scientists can meticulously examine glutathionylation sites and dynamics, offering profound insights into cellular regulation mechanisms and responses to oxidative damage.
Nutritional Research: Serving as a tracer in nutritional investigations, Glutathione-[13C2,15N] trifluoroacetate salt serves as a cornerstone in exploring the biosynthesis and regulation of glutathione under diverse dietary paradigms. Researchers leverage its potential to probe the influence of nutrients and bioactive compounds on glutathione metabolism and antioxidant defenses, paving the way for the development of tailored dietary interventions for enhancing overall health and well-being.
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