Boc-Gly-OH-[2-13C]

Boc-Gly-OH-[2-13C] is a labeled amino acid derivative used in various advanced bioscience applications. Here are some key applications of Boc-Gly-OH-[2-13C]:

Stable Isotope Labeling: Boc-Gly-OH-[2-13C] is used in stable isotope labeling to track metabolic pathways and biochemical reactions. By incorporating this labeled compound into proteins, researchers can monitor metabolic fluxes using mass spectrometry or nuclear magnetic resonance (NMR). This provides valuable insights into cellular metabolism and enzyme activities.

NMR Spectroscopy: Boc-Gly-OH-[2-13C] is frequently used in NMR spectroscopy to elucidate protein structures and dynamics. The [2-13C] label improves signal detection, facilitating detailed atomic-level analysis of biomolecules. This helps in understanding protein folding, interactions, and conformational changes.

Pharmacokinetic Studies: In pharmacokinetics, Boc-Gly-OH-[2-13C] aids in studying the absorption, distribution, metabolism, and excretion of drugs. The stable isotope label allows for precise tracking of drug metabolites in biological systems. This enhances the evaluation of drug safety and efficacy.

Proteomics Research: Boc-Gly-OH-[2-13C] is utilized in proteomics to quantify and compare protein expression levels in different conditions. The labeled amino acid can be incorporated into proteins during synthesis, enabling accurate mass spectrometric analysis. This application is essential for discovering biomarkers and understanding protein function in health and disease.