CAS 1216432-55-1 Hydroxychloroquine-[d4]

General Information
Catalog: BLP-012700
CAS: 1216432-55-1
Molecular Formula: C18H22D4ClN3O
Molecular Weight: 339.90

General Information

Catalog: BLP-012700

CAS: 1216432-55-1

Molecular Formula: C18H22D4ClN3O

Molecular Weight: 339.90

Chemical Structure

Description	Hydroxychloroquine-[d4] is the labelled analogue of Hydroxychloroquine, which is a lupus erythematosus suppressant with antimalarial and rheumatic effects.
Synonyms	2-[{4-[(7-Chloro-4-quinolinyl)amino](1,1,2,2-2H4)pentyl}(ethyl)amino]ethanol; Hydroxychloroquine-d4; 7-Chloro-4-[4-[ethyl(2-hydroxyethyl)amino]-1-methylbutylamino]-quinoline-d4; Plaquenil-d4; Oxichloroquine-d4; Oxychlorochin-d4; Oxychloroquine-d4
IUPAC Name	2-[[4-[(7-chloroquinolin-4-yl)amino]-1,1,2,2-tetradeuteriopentyl]-ethylamino]ethanol
Related CAS	118-42-3 (unlabelled) 747-36-4 (unlabelled sulfate) 1216432-56-2 (sulfate)
Canonical SMILES	CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO
InChI	InChI=1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21)/i4D2,10D2
InChI Key	XXSMGPRMXLTPCZ-NVKMLNCQSA-N
Solubility	Soluble in Chloroform (Slightlly), DMSO (Slightly), Methanol (Slightly)
Appearance	White Solid
Storage	Store at 2-8°C

Hydroxychloroquine-[d4], a deuterated derivative of hydroxychloroquine, plays a pivotal role in research and development, shedding light on the intricate pharmacokinetics and dynamics of its parent compound. Here are the key applications of Hydroxychloroquine-[d4]:

Pharmacokinetic Studies: Utilizing Hydroxychloroquine-[d4] in pharmacokinetic investigations unveils the drug's absorption, distribution, metabolism, and excretion pathways. Through the utilization of a deuterated form, researchers can meticulously track and distinguish the compound from endogenous substances using cutting-edge mass spectrometry techniques. This precision enables the precise quantification and in-depth scrutiny of the drug’s behavior within the physiological milieu.

Drug Metabolism Research: This remarkable compound serves as a cornerstone in delving into the intricate metabolic pathways of hydroxychloroquine. By monitoring the deuterium-labeled molecule, scientists can pinpoint the specific enzymes and pathways involved in the drug's biotransformation journey. This profound understanding is pivotal for deciphering potential drug interactions, anticipating side effects, and optimizing therapeutic protocols, shaping the landscape of personalized medicine.

Bioavailability Assessment: Hydroxychloroquine-[d4] emerges as a game-changer in assessing the bioavailability of hydroxychloroquine across diverse formulations. The comparative analysis of bioavailability among different formulations is a cornerstone in refining the development of cutting-edge and safer drug delivery systems. This innovative application serves as a cornerstone for enhancing drug design paradigms and fine-tuning dosing strategies for optimal therapeutic outcomes.