α-Hydroxymetoprolol-[d7] (iso-propyl-[d7])

α-Hydroxymetoprolol-[d7] (iso-propyl-[d7]), a deuterated compound utilized primarily in analytical and research settings, holds a key role in various applications. Here are the key applications of α-Hydroxymetoprolol-[d7] (iso-propyl-[d7]):

Pharmacokinetic Studies: Serving as an internal standard in pharmacokinetic investigations, this compound enables precise quantification of α-Hydroxymetoprolol concentrations in biological samples. Deuterium labeling distinguishes it from the non-labeled form, aiding in the accurate assessment of absorption, distribution, metabolism, and excretion (ADME) profiles of metoprolol. This method sheds light on the intricate journey of the drug within the body.

Drug Metabolism Research: Delving into the metabolic pathways of metoprolol, α-Hydroxymetoprolol-[d7] is a cornerstone in drug metabolism inquiries. By comparing the metabolism rates of labeled and unlabeled compounds, researchers uncover valuable insights into enzymatic activity. This knowledge is pivotal for anticipating drug interactions and refining drug design, shaping the future of pharmaceutical development.

Analytical Method Development: Playing a vital role in methodological advancements, this compound aids in the development and validation of analytical techniques like liquid chromatography-mass spectrometry (LC-MS). Stable isotope labeling ensures precise quantification of metoprolol and its metabolites, guaranteeing accuracy and reliability in bioanalytical assays. Such advancements set a high standard for analytical precision and efficacy.

Bioavailability Studies: Employed in bioavailability assessments, α-Hydroxymetoprolol-[d7] evaluates the pharmacological performance of metoprolol formulations. Through the use of this labeled compound, researchers monitor the bioequivalence between different formulations, a critical step in the development of generic drugs and the maintenance of consistent therapeutic outcomes. This application marks a pivotal contribution to pharmaceutical research and development.