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Imatinib-[d3]

General Information
Catalog: BLP-012390
CAS: 1134803-18-1
Molecular Formula: C29H28D3N7O
Molecular Weight: 496.62
Chemical Structure
Imatinib-[d3]
Description Imatinib-[d3] is the labelled analogue of Imatinib. Imatinib can be used for the treatment of chronic myelogenous leukemia and acute lymphocytic leukemia.
Synonyms Imatinib D3; Genfatinib-d3; 4-[[4-(methyl-d3)-1-piperazinyl]methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide
IUPAC Name N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]-4-[[4-(trideuteriomethyl)piperazin-1-yl]methyl]benzamide
Related CAS 152459-95-5 (unlabelled)
Canonical SMILES CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5
InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)/i2D3
InChI Key KTUFNOKKBVMGRW-BMSJAHLVSA-N
Melting Point >195°C (dec.)
Purity 95% by HPLC; 99% atom D
Density 1.3±0.1 g/cm3
Solubility Soluble in DMSO, Methanol
Appearance White to Pale Yellow Solid
Storage Store at -20°C

Imatinib-[d3], a deuterated variant of the tyrosine kinase inhibitor Imatinib, finds widespread utility in both research and clinical domains. Listed below are its key applications:

Pharmacokinetic Studies: Imatinib-[d3] plays a pivotal role in delving into the pharmacokinetics of the drug encompassing aspects such as absorption, distribution, metabolism, and excretion. Its deuterated composition enables precise tracking via mass spectrometry, unfettered by interference from endogenous compounds. This analytical tool sheds light on the drug's behavior within the body, facilitating the optimization of dosage regimens for enhanced therapeutic outcomes.

Drug Metabolism Research: Leveraging Imatinib-[d3] as a research asset allows for an in-depth exploration of the metabolic pathway undertaken by Imatinib, unveiling insights into its stability and breakdown relative to its non-deuterated counterpart. Researchers can pinpoint the metabolic enzymes at play and evaluate potential interactions with other drugs. This knowledge proves invaluable in refining the safety and efficacy profiles of the medication, bolstering patient care standards.

Therapeutic Drug Monitoring: Within clinical milieus, Imatinib-[d3] serves as a steadfast internal standard for monitoring Imatinib levels in patients, aiding experts in achieving precise quantification for optimal therapeutic concentrations. This personalized approach not only elevates treatment efficacy but also mitigates the occurrence of adverse effects, enhancing patient well-being through tailored medication regimens.

Research Tool for Resistance Mechanisms: Imatinib-[d3] emerges as a vital instrument in probing the mechanisms underpinning resistance in cancer cells, notably in chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). By scrutinizing how cancer cells adapt to Imatinib treatment and develop resistance, scientists gain crucial insights for devising strategies to surmount such challenges and elevate patient outcomes, underscoring the pivotal role of this research tool in advancing cancer therapeutics.

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