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Irinotecan-[d10]

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General Information
Catalog: BLP-013574
CAS: 718613-28-6
Molecular Formula: C33H28D10N4O6
Molecular Weight: 596.74

Chemical Structure

Description	Labelled Irinotecan. Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively. It is used for the treatment of colon and rectum cancers. It binds to topoisomerase I-DNA complex, preventing religation of the DNA strand and leading to double-strand DNA breakage and cell death.
Related CAS	97682-44-5 (unlabelled)