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iso-Colchicine-[d3]

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General Information
Catalog: BLP-005835
CAS: 1246818-69-8
Molecular Formula: C22H22D3NO6
Molecular Weight: 402.46

Chemical Structure

Description	iso-Colchicine-[d3] is an isotopically labelled analogue of iso-Colchicine, an isotopically labelled antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Synonyms	N-[(7S)-5,6,7,10-Tetrahydro-1,2,3,9-tetramethoxy-10-oxobenzo[a]heptalen-7-yl]acetamide-d3; Isocolchicine d3
IUPAC Name	2,2,2-trideuterio-N-[(7S)-1,2,3,9-tetramethoxy-10-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Related CAS	518-12-7 (unlabelled)
Canonical SMILES	CC(=O)NC1CCC2=CC(=C(C(=C2C3=C1C=C(C(=O)C=C3)OC)OC)OC)OC
InChI	InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-17(25)18(26-2)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1/i1D3
InChI Key	MDYALASTPGGXQH-AVSFSGARSA-N
Melting Point	148-153°C
Purity	97% by CP; 98% atom D
Appearance	Faintly Yellow Crystalline Powder
Storage	Store at -20°C