L-Arginine-[1-13C,alpha-15N] hydrochloride

L-Arginine-[1-13C,alpha-15N] hydrochloride is a stable isotope-labeled amino acid with important applications in research and diagnostics. Here are some key applications of L-Arginine-[1-13C,alpha-15N] hydrochloride:

Metabolic Tracing: In metabolic studies, L-Arginine-[1-13C,alpha-15N] hydrochloride is used as a tracer to investigate amino acid metabolism. By incorporating this labeled compound into biochemical pathways, researchers can track its conversion and utilization within the body. This application provides insights into metabolic disorders and the dynamic regulation of arginine-related pathways.

Protein Synthesis Studies: Researchers use L-Arginine-[1-13C,alpha-15N] hydrochloride to study protein synthesis and turnover in both in vitro and in vivo systems. By detecting the incorporation of labeled arginine into proteins, scientists can quantify rates of synthesis and degradation. This application is crucial for understanding cellular processes like muscle protein dynamics and the effects of nutritional interventions.

Clinical Diagnostics: In clinical research, L-Arginine-[1-13C,alpha-15N] hydrochloride is applied in diagnostic tests to evaluate nitric oxide production and urea cycle function. The labeled arginine allows for precise measurement of metabolic fluxes associated with cardiovascular and hepatic functions. This information is valuable in diagnosing and monitoring diseases like hypertension and liver dysfunction.

Nutritional Research: L-Arginine-[1-13C,alpha-15N] hydrochloride is utilized in nutritional studies to assess the impact of dietary interventions on arginine metabolism. Researchers can analyze how supplementation with labeled arginine affects nitrogen balance and amino acid interactions. Such studies contribute to optimizing dietary strategies for health and performance enhancement.