Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-013156 |
CAS: 178101-89-8 |
Molecular Formula: C5[13C]H8O6 |
Molecular Weight: 177.12 |
Chemical Structure |
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Description | L-Ascorbic acid-[2-13C] is the labelled analogue of Vitamin C. Vitamin C is a naturally occurring organic compound with antioxidant properties. |
Synonyms | L-Threoascorbic acid-2-13C; Antiscorbutic factor-2-13C; Vitamin C-2-13C; [2-13C]vitamin C |
IUPAC Name | (2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-(4-13C)2H-furan-5-one |
Related CAS | 50-81-7 (unlabelled) |
Canonical SMILES | C(C(C1C(=C(C(=O)O1)O)O)O)O |
InChI | InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1/i4+1 |
InChI Key | CIWBSHSKHKDKBQ-DXEGWCNNSA-N |
Melting Point | 190-194°C (dec) (lit.) |
Purity | ≥98% by CP; ≥99% atom 13C |
Solubility | Soluble in DMSO (Slightly), Methanol (Slightly) |
Appearance | Off-White to Pale Brown Solid |
Storage | Store at -20°C |
L-Ascorbic acid-[2-13C], a vitamin C variant with the 13C isotope replacing the second carbon atom, is a versatile tool with wide-ranging scientific applications. Here are the key applications of L-Ascorbic acid-[2-13C]:
Metabolic Tracing: Widely utilized in metabolic tracing experiments, L-Ascorbic acid-[2-13C] plays a crucial role in investigating the intricacies of vitamin C metabolism in biological systems. By meticulously tracking the labeled carbon, researchers embark on a journey through the pathways and transformations of vitamin C within cells and tissues, unraveling detailed insights into the bioavailability, distribution, and degradation of this essential nutrient.
Nutritional Studies: In the realm of nutritional research, L-Ascorbic acid-[2-13C] emerges as a valuable tool for probing the dietary absorption and utilization of vitamin C. By administering this labeled compound to study participants, scientists embark on an exploration of how efficiently the body absorbs and integrates vitamin C from diverse food sources. This knowledge is pivotal for shaping dietary recommendations and illuminating the intricate web of nutrient interactions within the body.
Pharmacokinetics: Stepping into the realm of pharmacokinetic studies, L-Ascorbic acid-[2-13C] stands as a cornerstone for unraveling the absorption, distribution, metabolism, and excretion of vitamin C. By juxtaposing the kinetics of the labeled and unlabeled forms, researchers delve into the physiological processing and potential therapeutic advantages of vitamin C supplements. This endeavor aids in refining dosage forms and devising optimal delivery strategies for clinical applications, ushering in a new era of precision medicine.
Isotope Dilution Analysis: Serving as a gold standard in isotope dilution mass spectrometry (IDMS), L-Ascorbic acid-[2-13C] elevates the quantification of vitamin C in biological samples to new heights of accuracy. By harnessing the labeled compound as an internal standard, analysts achieve unparalleled precision in measuring vitamin C concentrations, paving the way for groundbreaking research in biochemistry, clinical studies, and food science. This cutting-edge technique redefines the boundaries of analytical excellence, enabling a deeper understanding of the molecular mysteries that govern our biological world.
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