Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-009809 |
CAS: 109376-41-2 |
Molecular Formula: C2[13C]2H7NO4 |
Molecular Weight: 135.09 |
Chemical Structure |
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Description | L-Aspartic acid-[1,2-13C2] is a labelled L-Aspartic acid. Aspartic Acid is an α-amino acid used in the biosythesis of proteins. It is a non-essential amino acid for humans. |
IUPAC Name | (2S)-2-amino(1,2-13C2)butanedioic acid |
Related CAS | 56-84-8 (unlabelled) |
Canonical SMILES | C(C(C(=O)O)N)C(=O)O |
InChI | InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1/i2+1,4+1 |
InChI Key | CKLJMWTZIZZHCS-CJQZVISGSA-N |
Melting Point | >300°C (dec.)(lit.) |
Purity | 95% by HPLC; 99% atom 13C |
L-Aspartic acid-[1,2-13C2], a stable isotope-labeled compound, plays a pivotal role in scientific research for tracing biochemical pathways and metabolic studies. Here are key applications of L-Aspartic acid-[1,2-13C2] presented with high perplexity and burstiness:
Metabolic Flux Analysis: In the realm of metabolic research, L-Aspartic acid-[1,2-13C2] emerges as a potent tool for delineating the carbon flow within the intricate Krebs cycle. By introducing this labeled compound into cellular systems, researchers embark on a journey to track the carbon atom redistribution, unveiling invaluable insights into metabolic fluxes and pathway dynamics. This application stands as a cornerstone in unraveling the mysteries of cellular metabolism and fine-tuning metabolic engineering endeavors.
Protein Structure and Function Studies: Delving into the realm of protein dynamics and interactions, labeled L-Aspartic acid-[1,2-13C2] stands as an indispensable asset. Employing techniques like NMR spectroscopy, researchers leverage this compound to embed structural changes and map binding sites with unparalleled precision. This meticulous exploration not only enhances the comprehension of protein functions but also catalyzes the design of drugs tailored to target specific protein regions, heralding a new era in drug discovery.
Enzyme Mechanism Investigation: At the heart of enzyme mechanism exploration lies the strategic deployment of L-Aspartic acid-[1,2-13C2]. By scrutinizing the mechanisms of enzymes that engage with aspartic acid or its derivatives, researchers unveil the hidden roles of specific enzymes in catalysis and substrate conversion. This profound analysis not only fuels the development of targeted inhibitors or activators for therapeutic ends but also sheds light on the intricate dance of molecular interactions within biological systems.
Cellular Respiration Studies: Within the realm of cellular respiration, L-Aspartic acid-[1,2-13C2] assumes a central role in dissecting how cells harness substrates to fuel the energy production machinery. Guided by this compound, researchers embark on a journey to label metabolic intermediates, unraveling the cryptic processes underlying energy production mechanisms like oxidative phosphorylation. This treasure trove of information not only enriches our grasp of cellular energetics but also holds promise in shaping interventions for combating metabolic disorders, paving the way for transformative breakthroughs in the field.
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