L-citrulline-[ureido-13C,5,5-d2]

L-citrulline-[ureido-13C,5,5-d2], a stable isotope-labeled variant of L-citrulline, finds widespread use in diverse research and clinical settings. Here are the key applications of L-citrulline-[ureido-13C,5,5-d2]:

Metabolic Pathway Studies: Serving as a cornerstone in metabolic investigations, L-citrulline-[ureido-13C,5,5-d2] is instrumental in tracing and quantifying the intricate pathways of the urea cycle and nitric oxide synthesis. By integrating this labeled derivative, researchers can track the fluxes and conversions within metabolic processes in real time, offering meticulous insights into the dynamic nature of metabolic pathways and the pivotal role played by L-citrulline in human physiology.

Nutritional Research: In the realm of nutritional exploration, researchers rely on L-citrulline-[ureido-13C,5,5-d2] to unravel the impact of dietary supplements on nitric oxide generation and vascular well-being. By scrutinizing the metabolic destiny of L-citrulline within human subjects, scientists can evaluate its effectiveness and bioconversion in augmenting nitric oxide levels. This knowledge forms the bedrock for devising efficacious dietary interventions aimed at enhancing cardiovascular health, underscoring the significance of L-citrulline in promoting overall well-being.

Pharmacokinetics: Vital for both preclinical and clinical drug development endeavors, L-citrulline-[ureido-13C,5,5-d2] is harnessed to unravel the intricate pharmacokinetic profiles of formulations containing L-citrulline. Through meticulous tracking of the absorption, distribution, metabolism, and excretion of this labeled derivative, researchers unlock crucial insights into the bioaccessibility and therapeutic potential of novel L-citrulline-based pharmaceuticals. This comprehensive understanding aids in refining dosing strategies and enhancing drug efficacy, paving the way for optimized therapeutic outcomes.