L-Glutamic acid-[1-13C]

L-Glutamic acid-[1-13C] is a labeled amino acid used as a tracer in metabolic studies and research. Here are some key applications of L-Glutamic acid-[1-13C]:

Metabolic Flux Analysis: L-Glutamic acid-[1-13C] is widely used in metabolic flux analysis to trace carbon atoms through metabolic pathways. By incorporating this labeled compound into cells or organisms, researchers can monitor the fate of the carbon label using techniques like NMR or mass spectrometry. This provides insights into the dynamic changes and regulation of metabolic networks.

Brain Metabolism Studies: In neuroscience, L-Glutamic acid-[1-13C] is employed to study neuronal and glial cell metabolism. It helps in understanding the glutamate-glutamine cycle and the metabolic interactions between different cell types in the brain. This information is crucial for research into neurological diseases and brain function.

Cancer Research: L-Glutamic acid-[1-13C] is utilized in cancer research to investigate altered metabolic pathways in tumor cells. By tracking the labeled glutamate, scientists can study the metabolic adaptations that cancer cells undergo to support their rapid growth and survival. This aids in identifying potential metabolic targets for cancer therapy.

Nutritional Studies: L-Glutamic acid-[1-13C] can be used in nutritional research to study amino acid metabolism and dietary protein utilization. By observing the incorporation of the labeled glutamate into different metabolic products, researchers can evaluate the efficiency of protein digestion and amino acid absorption. This application has implications for developing dietary interventions and improving nutritional health.