Name: L-Histidine-[13C6,15N3]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-009876

CAS: 1219114-75-6

Molecular Formula: [13C]6H9[15N]3O2

Molecular Weight: 164.09

Chemical Structure

Description	L-Histidine-[13C6,15N3] is a labelled L-Histidine. Histidine is an α-amino acid used in the biosynthesis of proteins. Histidine is essential for humans that is metabolized to histamine.
Synonyms	L-Histidine-ul-13C,15N
IUPAC Name	(2S)-2-(15N)azanyl-3-((2,4,5-13C3,1,3-15N2)1H-imidazol-5-yl)(1,2,3-13C3)propanoic acid
Related CAS	741656-40-6 71-00-1 (unlabelled)
Canonical SMILES	C1=C(NC=N1)CC(C(=O)O)N
InChI	InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1/i1+1,2+1,3+1,4+1,5+1,6+1,7+1,8+1,9+1
InChI Key	HNDVDQJCIGZPNO-SOVAVUQXSA-N
Melting Point	282°C(lit.)
Purity	95% by HPLC; 99% atom 13C, 98% atom 15N

L-Histidine-[13C6,15N3], a stable isotope-labeled amino acid widely utilized in scientific research, offers a multitude of applications. Here are key applications of L-Histidine-[13C6,15N3] presented with high perplexity and burstiness:

Metabolic Tracing: Delving into metabolic studies, L-Histidine-[13C6,15N3] acts as a tracer, shedding light on histidine metabolism within diverse biological systems. Through monitoring the labeled isotope's journey, researchers unveil insights into metabolic pathways and histidine's utilization in protein synthesis and amino acid recycling. This knowledge plays a pivotal role in comprehending metabolic diseases and devising targeted interventions with precision.

NMR Spectroscopy: At the forefront of nuclear magnetic resonance (NMR) spectroscopy, L-Histidine-[13C6,15N3] elevates the examination of protein structure and dynamics to the atomic level. By integrating stable isotopes, the sensitivity and resolution of NMR signals are enhanced, facilitating detailed characterization of protein folding, interactions, and conformational changes. This application stands as a cornerstone in drug discovery and structural biology research, driving forward innovation in molecular studies.

Protein Expression Studies: Within the realm of protein research, L-Histidine-[13C6,15N3] is harnessed to delve into the biosynthesis and degradation processes of proteins. Through the analysis of isotope-labeled proteins using mass spectrometry, scientists quantify protein turnover rates, evaluating the impact of genetic or environmental alterations. Such intricate studies provide insights into protein homeostasis and its implications in related diseases, fostering a deeper understanding of cellular processes.

Clinical Research: In the domain of clinical research, L-Histidine-[13C6,15N3] serves as a cornerstone in exploring amino acid metabolism within human health and disease. By administering this labeled compound, researchers uncover histidine's role in conditions such as metabolic disorders, cancer, and neurological diseases.