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L-Homoarginine-[13C7,15N4] hydrochloride

General Information
Catalog: BLP-009039
Molecular Formula: [13C]7H17[15N]4O2Cl
Molecular Weight: 235.61
Chemical Structure
L-Homoarginine-[13C7,15N4] hydrochloride
Description L-Homoarginine-[13C7,15N4] hydrochloride is a labelled analog of Homoarginine. L-Homoarginine may be used to create non-natural proteins for studies of post-translational protein modifications.
Synonyms H-HomoArg-OH HCl 13C7,15N4
IUPAC Name N6-(di(amino-15N)methylene-13C)-L-lysine-13C6-15N2 hydrochloride
Related CAS 1483-01-8 (unlabelled)
Purity 98% by CP; 98% atom 13C; 98% atom 15N
Solubility Soluble in Methanol, Water
Appearance White to Pale Beige Solid
Storage Store at -20°C

L-Homoarginine-[13C7,15N4] hydrochloride, a stable isotope-labeled amino acid, finds utility across diverse scientific research domains. Here are key applications of L-Homoarginine-[13C7,15N4] hydrochloride, detailed with a high degree of perplexity and burstiness:

Metabolic Tracing: Laden with carbon-13 and nitrogen-15 isotopes, L-Homoarginine-[13C7,15N4] hydrochloride serves as a linchpin in metabolic tracing endeavors, dissecting intricate metabolic pathways and fluxes. By integrating this compound into metabolic assays, researchers can meticulously trail the biochemical trajectories and conversions of homoarginine through isotopic scrutiny. This methodology offers nuanced insights into amino acid metabolism dynamics, shedding light on associated disorders lurking in the metabolic realm.

Proteomics Research: Within the realm of proteomics, L-Homoarginine-[13C7,15N4] hydrochloride assumes the role of an internal standard or a spike-in standard for mass spectrometry-based experiments. Leveraging isotope-labeled standards, scientists attain precise quantification of proteins within intricate biological samples. This meticulous approach fortifies the reliability of proteomic data, amplifying investigations into protein function intricacies and regulatory mechanisms governing the proteome's intricacy.

Pharmacokinetics Studies: The isotopic enrichment of L-Homoarginine augments its relevance in pharmacokinetic inquiries, where it becomes instrumental in probing the absorption, distribution, metabolism, and excretion dynamics of drugs connected to the homoarginine pathways. Tracing the compound's journey through physiological systems empowers researchers to delineate crucial pharmacokinetic parameters underpinning drug actions. This knowledge bolsters the refinement of drug formulation strategies and enhances delivery modalities, driving precision in therapeutic interventions.

Biological Pathway Elucidation: Embraced as a tool to unravel the enigmas of biological pathways like cardiovascular function and nitric oxide metabolism, L-Homoarginine-[13C7,15N4] hydrochloride serves as a beacon for scientists seeking insights into the intricate tapestry of homoarginine's involvement. Through isotope tracing methodologies, researchers embark on a profound exploration of how homoarginine interplays with these pathways, unraveling its potential implications for health conditions. This enriched understanding serves as a compass for devising targeted therapeutic interventions aimed at modulating specific pathways, paving the way for precision medicine endeavors.

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