Name: L-Lysine-[6-13C,epsilon-15N] Dihydrochloride
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-009059

CAS: 312623-81-7

Molecular Formula: C5[13C]H16Cl2N[15N]O2

Molecular Weight: 221.10

Chemical Structure

Description	L-Lysine-[6-13C,epsilon-15N] Dihydrochloride is the labelled analogue of L-Lysine Dihydrochloride, which is a naturally occurring amino acid used in the labelling of human bone marrow mesenchymal stem cells for analysis.
Synonyms	L-lysine 2HCl 6-13C,epsilon-15N; L-Lysine-6-13C,epsilon-15N 2HCl; L-lysine-6-13C-epsilon-15N dihydrochloride
IUPAC Name	2-amino-6-(15N)azanyl(6-13C)hexanoic acid;dihydrochloride
Related CAS	657-26-1 (unlabelled)
Canonical SMILES	C(CCN)CC(C(=O)O)N.Cl.Cl
InChI	InChI=1S/C6H14N2O2.2ClH/c7-4-2-1-3-5(8)6(9)10;;/h5H,1-4,7-8H2,(H,9,10);2*1H/i4+1,7+1;;
InChI Key	JBBURJFZIMRPCZ-YXQIJENGSA-N
Purity	98% by CP; 99% atom 13C; 98% atom 15N
Storage	Store at RT

L-Lysine-[6-13C,epsilon-15N] Dihydrochloride, a stable isotope-labeled amino acid, finds extensive use in scientific research and industrial applications. Here are key applications of this compound presented with high perplexity and burstiness:

Metabolic Tracing Studies: Playing a pivotal role in metabolism research, L-Lysine-[6-13C,epsilon-15N] Dihydrochloride serves as a tracer to unravel amino acid turnover and metabolic pathways. By scrutinizing the integration of this labeled compound into metabolic products, researchers glean profound insights into protein metabolism and nutrient utilization. This technique proves particularly valuable for deciphering metabolic diseases and monitoring the impacts of nutritional interventions.

Protein Structure Analysis: Employed in nuclear magnetic resonance (NMR) spectroscopy, L-Lysine-[6-13C,epsilon-15N] Dihydrochloride enhances the visibility of lysine residues, enabling scientists to delve into protein structures with heightened precision. The isotopic labeling facilitates the study of protein folding, interactions, and dynamics, essential for unlocking new biomolecules and comprehending molecular mechanisms within biological systems.

Pharmacokinetic Studies: In the realm of drug development, L-Lysine-[6-13C,epsilon-15N] Dihydrochloride is a valuable tool for investigating the pharmacokinetics of lysine-containing compounds. By tracing the labeled lysine within biological systems, researchers evaluate the absorption, distribution, metabolism, and excretion of pharmaceuticals. This data aids in refining drug formulations and enhancing therapeutic efficacy, pushing the boundaries of pharmacological research.

Quantitative Proteomics: Integral to quantitative proteomics, L-Lysine-[6-13C,epsilon-15N] Dihydrochloride facilitates the precise measurement of protein abundances in complex samples. Through stable isotope labeling by amino acids in cell culture (SILAC), researchers compare protein expression levels across different conditions, unveiling potential biomarkers and unraveling cellular responses to various stimuli at a deeper level.