CAS 263568-73-6 L-Methionine-[13C,d3] - Isotope / BOC Sciences

General Information
Catalog: BLP-001681
CAS: 263568-73-6
Molecular Formula: C4[13C]H8D3NO2S
Molecular Weight: 153.22

General Information

Catalog: BLP-001681

CAS: 263568-73-6

Molecular Formula: C4[13C]H8D3NO2S

Molecular Weight: 153.22

Chemical Structure

Description	L-Methionine-[13C,d3] is the labelled analogue of L-Methionine. L-methionine is a non-polar α-amino acid with a straight side chain that possess a S-methyl thioether (i.e. C-S-C bonding) at the γ-carbon. It is an essential amino acid in all metazoa and is coded by the initiation codon AUG, which also indicates mRNA's coding region where translation into protein begins. Protein supplement in health care products.
Synonyms	SILAC Amino Acid; L-Methionine-(carboxy-13C,methyl-d3); L-Methionine-1-13C,methyl-d3
IUPAC Name	(2S)-2-amino-4-(trideuteriomethylsulfanyl)(1-13C)butanoic acid
Related CAS	63-68-3 (unlabelled)
Canonical SMILES	CSCCC(C(=O)O)N
InChI	InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1/i1D3,5+1
InChI Key	FFEARJCKVFRZRR-YLXZAIPNSA-N
Melting Point	284 °C (dec.)
Purity	99% atom 13C; 99% atom D

L-Methionine-[13C,d3], a stable isotope-labeled amino acid, finds diverse applications in bioscience. Here are the key applications of L-Methionine-[13C,d3]:

Metabolic Tracing: Delving into metabolic tracing studies, researchers utilize L-Methionine-[13C,d3] to track methionine metabolism and its derivatives across various biological pathways. By integrating this labeled amino acid into cells or organisms, scientists can monitor its incorporation and transformation in real-time using cutting-edge mass spectrometry techniques. This immersive approach provides intricate insights into metabolic fluxes and the dynamic interplay of pathways.

Protein Turnover Studies: At the core of investigating protein dynamics, L-Methionine-[13C,d3] serves as a pivotal tool for analyzing protein synthesis and degradation rates within cellular systems. By quantifying the incorporation of this labeled amino acid into newly synthesized proteins and its depletion from degrading proteins, scientists can precisely measure protein turnover. This data is paramount for unraveling cellular protein equilibrium and the nuanced proteome remodeling dynamics under varying environmental cues.

Methylation Research: In the realm of epigenetic exploration, L-Methionine-[13C,d3] emerges as a key player in elucidating methylation processes. Functioning as a precursor to S-adenosylmethionine (SAM), the primary methyl group donor in cellular processes, this labeled methionine facilitates comprehensive investigations into methylation patterns on DNA, RNA, and proteins. Researchers harness this information to probe the intricate interplay between methylation, gene regulation, and cellular functionality.

Pharmacokinetic Studies: Steering into the realm of clinical and pharmaceutical inquiry, L-Methionine-[13C,d3] serves as a vital asset for dissecting the pharmacokinetics of methionine and its analogs. By administering the labeled compound and meticulously monitoring its absorption, distribution, metabolism, and excretion, researchers can glean invaluable insights into the behavior of methionine-based drugs. This comprehensive approach aids in optimizing dosing protocols and enhancing the therapeutic efficacy of interventions.