L-Serine-[2,3-13C2]

L-Serine-[2,3-13C2] is a stable isotope-labeled compound used extensively in scientific research. Here are some key applications of L-Serine-[2,3-13C2]:

Metabolic Tracing: L-Serine-[2,3-13C2] is utilized in metabolic studies to trace serine and its metabolic pathways within biological systems. By incorporating this labeled compound, researchers can follow its uptake and transformation in cells and tissues. This application helps in understanding serine's role in metabolism and its implications in various conditions such as cancer and neurological disorders.

NMR Spectroscopy: In nuclear magnetic resonance (NMR) spectroscopy, L-Serine-[2,3-13C2] serves as a valuable tool for studying the structural dynamics of proteins and other biomolecules. The labeled carbons enhance the visibility and interpretation of NMR signals, providing detailed insights into molecular interactions and conformational changes. This proves essential for drug design and understanding complex biological processes.

Stable Isotope-Resolved Metabolomics (SIRM): L-Serine-[2,3-13C2] is a key component in SIRM studies, where it aids in the detailed examination of metabolic networks. By measuring the incorporation of the 13C label into downstream metabolites, researchers can elucidate pathway activities and fluxes. This technique is crucial for exploring metabolic alterations in diseases and the effects of therapeutic interventions.

Cancer Research: In cancer biology, L-Serine-[2,3-13C2] is employed to investigate altered metabolic pathways in tumor cells. By analyzing the distribution of the labeled serine in cancer cell metabolism, scientists can identify potential metabolic vulnerabilities and therapeutic targets. This information is vital for developing metabolic-based therapies and understanding the metabolic underpinnings of cancer progression.