L-Tyrosine-[2-13C]

L-Tyrosine-[2-13C], an amino acid enriched with isotopic labeling, finds diverse applications in bioscience. Here are the key applications of L-Tyrosine-[2-13C]:

Metabolic Flux Analysis: Widely employed in metabolic flux analysis, L-Tyrosine-[2-13C] serves as a critical tool for tracing and quantifying metabolic pathways within cells. By integrating the labeled tyrosine into cellular metabolism, researchers can meticulously monitor its transformation into downstream metabolites. This approach facilitates a nuanced comprehension of cellular metabolism dynamics, pinpointing potential metabolic bottlenecks that may impede optimal functionality.

Protein Labeling and Structural Studies: In the realm of protein labeling and structural analyses, L-Tyrosine-[2-13C] emerges as a pivotal resource for investigating protein structures and interactions through techniques like NMR spectroscopy. The incorporation of the 13C label enables precise tracking of tyrosine residues within the protein structure, unveiling valuable insights into protein folding, conformational changes, and binding interactions. This methodological approach sheds light on the intricate world of protein architecture and function.

Diagnostics and Imaging: Harnessing the power of 13C labeling, L-Tyrosine-[2-13C] becomes an invaluable asset in diagnostic imaging modalities such as PET (positron emission tomography), facilitating in vivo exploration of disease mechanisms. By monitoring the distribution and metabolism of the labeled tyrosine, clinicians can capture detailed images of metabolic activities within tissues, offering crucial insights for diagnosing and monitoring conditions like cancer. This application stands at the forefront of cutting-edge medical imaging technology.

Neuroscience Research: Delving into the realm of neuroscience, L-Tyrosine-[2-13C] emerges as a key player in unraveling the biosynthesis and regulation of neurotransmitters like dopamine and norepinephrine. Researchers leverage the marked tyrosine to track its integration into these neurotransmitters, unraveling the complex dynamics of neural function and neurotransmitter activity. This exploration is pivotal for advancing our understanding of neurological disorders and forging novel therapeutic strategies aimed at enhancing brain health and function.