Name: L-Tyrosine-[d7]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-009550

CAS: 130551-49-4

Molecular Formula: C9H4D7NO3

Molecular Weight: 188.23

Chemical Structure

Description	L-Tyrosine-[d7] is a labelled L-tyrosine. Tyrosine is a non-essential amino acid synthesized from phenylalanine. It is the precursor of some neurotransmitters.
Synonyms	L-4-Hydroxyphenyl-d4-alanine-2,3,3-d3; L-Tyrosine-d7; p-Hydroxyphenyl-L-alanine-d7; H-L-Tyr-OH-d7
IUPAC Name	(2S)-2,3,3-trideuterio-2-(dideuterioamino)-3-(2,3-dideuterio-4-hydroxyphenyl)propanoic acid
Related CAS	60-18-4 (unlabelled)
Isomeric SMILES	[2H]C1=C(C(=C(C(=C1C([2H])([2H])[C@@]([2H])(C(=O)O)N)[2H])[2H])O)[2H]
Canonical SMILES	C1=CC(=CC=C1CC(C(=O)O)N)O
InChI	InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1/i1D,2D,3D,4D,5D2,8D
InChI Key	OUYCCCASQSFEME-BKKGXISKSA-N
Purity	98% by CP; 98% atom D
Appearance	White Solid

L-Tyrosine-[d7] is a stable isotope-labeled form of the amino acid tyrosine used widely in bioscience research. Here are some key applications of L-Tyrosine-[d7]:

Metabolic Flux Analysis: L-Tyrosine-[d7] is employed in metabolic flux analysis to trace biochemical pathways in cells. By incorporating the labeled tyrosine, researchers can monitor its incorporation into proteins and other metabolites. This helps in understanding metabolic rates and pathway dynamics under various physiological conditions.

Proteomics: In proteomics research, L-Tyrosine-[d7] aids in the identification and quantification of proteins through mass spectrometry. The labeled tyrosine provides a distinct mass signature, allowing for precise measurements of protein abundance and turnover. This technique is crucial for studying protein expression, post-translational modifications, and interactions in complex biological samples.

Pharmacokinetics: L-Tyrosine-[d7] is used in pharmacokinetic studies to assess the absorption, distribution, metabolism, and excretion of tyrosine-related drugs. By tracking the labeled amino acid, scientists can gather detailed information on drug metabolism and bioavailability. These insights inform dosage optimization and the development of new therapeutic agents.

Nutritional Research: In nutritional science, L-Tyrosine-[d7] helps in studying amino acid metabolic pathways and dietary protein utilization. Researchers can use the labeled tyrosine to explore the effects of different diets and supplementation on amino acid uptake and metabolism. This knowledge aids in designing balanced nutritional plans and understanding metabolic disorders related to amino acid deficiencies.