CAS 286460-61-5 L-Valine-N-Boc-[1-13C]

General Information
Catalog: BLP-009574
CAS: 286460-61-5
Molecular Formula: C9[13C]H19NO4
Molecular Weight: 218.25

General Information

Catalog: BLP-009574

CAS: 286460-61-5

Molecular Formula: C9[13C]H19NO4

Molecular Weight: 218.25

Chemical Structure

Description	L-Valine-N-Boc-[1-13C] is a 13C labelled analogue of N-Boc-L-valine, which is used in the multi-peptide synthesis and serves as the amino acid protection monomer.
Synonyms	tert-Butoxycarbonylvaline-1-13C; Boc-Val-OH-1-13C
IUPAC Name	(2S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino](1-13C)butanoic acid
Related CAS	13734-41-3 (unlabelled)
Canonical SMILES	CC(C)C(C(=O)O)NC(=O)OC(C)(C)C
InChI	InChI=1S/C10H19NO4/c1-6(2)7(8(12)13)11-9(14)15-10(3,4)5/h6-7H,1-5H3,(H,11,14)(H,12,13)/t7-/m0/s1/i8+1
InChI Key	ZXBQTSZISFIAO-BAZIHRRBSA-N
Melting Point	77-80 °C (lit.)
Purity	98% by CP; 99% atom 13C
Appearance	White Solid
Storage	Store at -20°C

L-Valine-N-Boc-[1-13C] is a labeled amino acid derivative used in various scientific and industrial applications to study biological processes. Here are some key applications of L-Valine-N-Boc-[1-13C]:

Metabolic Tracing: L-Valine-N-Boc-[1-13C] is commonly used in metabolic tracing studies to follow the fate of valine in various biochemical pathways. By analyzing the incorporation of the 13C label, researchers can gain insights into amino acid metabolism and its interaction within cellular systems. This helps in understanding metabolic diseases and optimizing metabolic engineering strategies.

NMR Spectroscopy: This compound is valuable in nuclear magnetic resonance (NMR) spectroscopy for investigating the structure and dynamics of proteins. The 13C label serves as an isotopic marker, allowing researchers to study protein folding, stability, and interactions. This application is crucial for drug discovery and understanding protein-related functions in biological systems.

Isotope-Labeled Protein Production: L-Valine-N-Boc-[1-13C] can be used in the production of isotope-labeled proteins for structural studies. By incorporating the labeled amino acid during protein synthesis, scientists can create proteins suitable for detailed NMR or mass spectrometry analysis. This aids in elucidating complex protein structures and their functional mechanisms.

Biochemical Research: In biochemical research, L-Valine-N-Boc-[1-13C] is employed to study enzyme kinetics and substrate-channeling processes. The isotopic label allows precise measurement of reaction rates and enzyme activities in biological systems. This information is pivotal for characterizing enzyme functions and designing enzyme-based applications in industrial biotechnology.