CAS 1261432-01-2 Lacidipine-[13C8] - Isotope / BOC Sciences

General Information
Catalog: BLP-011598
CAS: 1261432-01-2
Molecular Formula: C18[13C]8H33NO6
Molecular Weight: 463.48

General Information

Catalog: BLP-011598

CAS: 1261432-01-2

Molecular Formula: C18[13C]8H33NO6

Molecular Weight: 463.48

Chemical Structure

Description	Lacidipine-[13C8] is the labelled analogue of Lacidipine, which is a dihydropyridine calcium channel blocker with antihypertensive activity.
Synonyms	Lacidipine 13C8; (E)-4-[2-[3-(1,1-Dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Diethyl Ester-13C8; Caldine-13C8; Lacipil-13C8; Lacirex-13C8; Motens-13C8; diethyl (E)-4-(2-(3-(tert-butoxy)-3-oxoprop-1-en-1-yl)phenyl)-2,6-di(methyl-13C)-1,4-dihydropyridine-3,5-dicarboxylate-2,3,5,6-13C4-3,5-13C2
IUPAC Name	diethyl 2,6-di((1-13C)methyl)-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]phenyl]-(2,3,5,6-13C4)1,4-dihydropyridine-3,5-dicarboxylate-3,5-13C2
Related CAS	103890-78-4 (unlabelled)
Canonical SMILES	CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2C=CC(=O)OC(C)(C)C)C(=O)OCC)C)C
InChI	InChI=1S/C26H33NO6/c1-8-31-24(29)21-16(3)27-17(4)22(25(30)32-9-2)23(21)19-13-11-10-12-18(19)14-15-20(28)33-26(5,6)7/h10-15,23,27H,8-9H2,1-7H3/b15-14+/i3+1,4+1,16+1,17+1,21+1,22+1,24+1,25+1
InChI Key	GKQPCPXONLDCMU-BBTGQLTHSA-N
Purity	95% by HPLC; 98% atom 13C
Solubility	Soluble in Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)
Appearance	White Solid
Storage	Store at -20°C

Lacidipine-[13C8], an isotopically labeled derivative of the calcium channel blocker lacidipine, finds diverse applications in scientific and medical research. Here are the key applications of Lacidipine-[13C8]:

Pharmacokinetics and Metabolism Studies: Delving into pharmacokinetic realms, Lacidipine-[13C8] is a cornerstone for exploring the intricate pathways of absorption, distribution, metabolism, and excretion of lacidipine within the human body. The [13C8] isotopic labeling offers a precise lens for tracing and quantifying the compound's journey through mass spectrometry. These meticulous analyses yield crucial insights into the drug's behavior, thereby shaping dosage regimens and administration protocols.

Drug Interaction Studies: Unraveling the mysteries of drug interactions, Lacidipine-[13C8] serves as a potent tool for scrutinizing potential interplays between lacidipine and other pharmaceutical agents. By leveraging this labeled compound, researchers can monitor fluctuations in drug metabolism and efficacy when co-administered with different medications. This investigative approach aids in identifying and mitigating adverse drug interactions, fostering safer clinical practices and patient outcomes.

Mechanistic Research: Immersed in the depths of mechanistic inquiries, Lacidipine-[13C8] is a beacon lighting the path to understanding the molecular intricacies of lacidipine's actions on calcium channels. The isotopic label acts as a gateway to detailed mass spectrometry analyses, unveiling the precise binding and interaction mechanisms of the drug at a molecular scale. This profound understanding not only enriches our comprehension of current treatments but also steers the design of future calcium channel blockers towards enhanced efficacy and precision.

Bioavailability Studies: In the realm of bioavailability assessments, Lacidipine-[13C8] emerges as a pivotal asset for gauging the entry kinetics and extent of lacidipine into systemic circulation. The utilization of this labeled compound enables the discrimination between the parent drug and its metabolites with unparalleled clarity. This distinction is paramount in refining drug formulations, ensuring consistent therapeutic outcomes across diverse patient cohorts, and propelling advancements in tailored healthcare practices.