Lamotrigine-[13C2,15N] - Isotope / BOC Sciences

General Information
Catalog: BLP-008982
Molecular Formula: C7[13C]2H7Cl2N4[15N]
Molecular Weight: 259.07

General Information

Catalog: BLP-008982

Molecular Formula: C7[13C]2H7Cl2N4[15N]

Molecular Weight: 259.07

Chemical Structure

Description	Lamotrigine-[13C2,15N] is the labelled analogue of Lamotrigine, which is used as a radiolabelled internal standard. Lamotrigine is an anticonvulsant, which inhibits glutamate release, possible through inhibition of sodium, potassium and calcium currents. It is used in treatment of bipolar depression.
Synonyms	Lamotrigine 5,6-13C2,5-amino-15N
IUPAC Name	6-(2,3-dichlorophenyl)-1,2,4-triazine-5,6-13C2-3,5-diamine-15N
Related CAS	84057-84-1 (unlabelled)
Purity	98% by CP; 99% atom 13C; 98% atom 15N
Storage	Store at -20°C

Lamotrigine-[13C2,15N], an isotopically labeled iteration of the anticonvulsant Lamotrigine, finds its primary utility in research endeavors. Here are the key applications of Lamotrigine-[13C2,15N]:

Pharmacokinetic Studies: Utilizing Lamotrigine-[13C2,15N] in pharmacokinetic investigations allows for meticulous tracking of the drug's absorption, distribution, metabolism, and excretion within the body. The isotopic labeling facilitates precise monitoring through mass spectrometry, offering intricate insights into the drug's behavior. This detailed understanding aids in refining dosing protocols and enhancing therapeutic efficacy.

Metabolite Identification: Researchers leverage Lamotrigine-[13C2,15N] for the identification and quantification of lamotrigine metabolites in both clinical and preclinical settings. The isotopic labeling streamlines the differentiation between the parent drug and its metabolites using sophisticated analytical tools. This knowledge is imperative for unraveling the drug's metabolic pathways and potential interactions, enabling a comprehensive grasp of its effects.

Bioequivalence Studies: In bioequivalence assessments, Lamotrigine-[13C2,15N] serves as a cornerstone for comparing the pharmacokinetic profiles of various lamotrigine formulations. By employing the labeled compound, researchers can precisely gauge bioavailability, ensuring that generic versions align with the standards set by the original drug. This process is vital for securing regulatory approval and facilitating the entry of generic medications into the market.

Drug-Drug Interaction Studies: The uniquely labeled Lamotrigine-[13C2,15N] is pivotal in exploring drug-drug interactions involving lamotrigine and other medications. Its distinctive labeling enables accurate monitoring even in the presence of concurrent drugs, shedding light on potential synergistic or antagonistic effects. This data is indispensable for formulating safe and efficient combination therapies, enhancing the landscape of medication interactions.