| Description |
Lapatinib-[13C2,15N] Ditosylate is the labelled salt of Lapatinib, which has potential antineoplastic activity. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases. |
| Synonyms |
Lapatinib-13C2,15N Ditosylate; N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine Bis(4-methylbenzenesulfonate)-13C2,15N Ditosylate; Tykerb-13C2,15N Ditosylate |
| IUPAC Name |
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonyl(1,2-13C2)ethyl(15N)amino)methyl]furan-2-yl]quinazolin-4-amine;4-methylbenzenesulfonic acid |
| Related CAS |
388082-77-7 (unlabelled)
|
| Canonical SMILES |
CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl |
| InChI |
InChI=1S/C29H26ClFN4O4S.2C7H8O3S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19;2*1-6-2-4-7(5-3-6)11(8,9)10/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);2*2-5H,1H3,(H,8,9,10)/i11+1,12+1,32+1;; |
| InChI Key |
UWYXLGUQQFPJRI-YZJTZNKBSA-N |
| Melting Point |
247-249°C |
| Purity |
≥95%; ≥98% atom 13C; ≥98% atom 15N |
| Solubility |
Soluble in DMSO; Sparingly soluble in Methanol |
| Appearance |
Yellow Solid |
| Storage |
Store at -20°C under inert atmosphere |
![Lapatinib-[13C2,15N] Ditosylate](/isotope.v1/images/structure-default.jpg)
