CAS 1133210-23-7 Levocetirizine-[d4] - Isotope / BOC Sciences

General Information
Catalog: BLP-012699
CAS: 1133210-23-7
Molecular Formula: C21H21D4ClN2O3
Molecular Weight: 392.92

General Information

Catalog: BLP-012699

CAS: 1133210-23-7

Molecular Formula: C21H21D4ClN2O3

Molecular Weight: 392.92

Chemical Structure

Description	Levocetirizine-[d4] is the labelled analogue of Levocetirizine, which is a histamine H1 receptor antagonist and could be used as an antihystaminic agent.
Synonyms	Levocetirizine D4; (R)-cetirizine-d4; Xyzal-d4; (-)-Cetirizine-d4; (R)-2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid-d4; 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy-1,1,2,2-d4]acetic acid
IUPAC Name	2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]-1,1,2,2-tetradeuterioethoxy]acetic acid
Related CAS	130018-77-8 (unlabelled) 130018-87-0 (unlabelled dihydrochloride)
Canonical SMILES	C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
InChI	InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)/t21-/m1/s1/i14D2,15D2
InChI Key	ZKLPARSLTMPFCP-KNFDVUFYSA-N
Purity	≥95%
Solubility	Soluble in DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Appearance	White Solid
Storage	Store at -20°C

Levocetirizine-[d4], a deuterated variant of the antihistamine levocetirizine, plays a pivotal role in the realms of pharmacokinetic and clinical research. Here are the key applications of Levocetirizine-[d4]:

Pharmacokinetic Studies: Positioned as an internal standard in the intricate realm of pharmacokinetics, Levocetirizine-[d4] meticulously traces the absorption, distribution, metabolism, and excretion pathways of levocetirizine. By juxtaposing this deuterated form with its non-deuterated counterpart, researchers gain the precision needed to quantify drug concentrations in biological samples with exactitude. This process aids in formulating optimal dosing strategies and refining safety profiles, enhancing the understanding of drug dynamics within the body.

Drug Interaction Studies: Critical for delving into potential drug-drug interactions involving levocetirizine, Levocetirizine-[d4] serves as an invaluable tool. By utilizing this stable isotope-labeled compound, researchers can discern and quantify the impact of co-administered drugs on the pharmacokinetics of levocetirizine. This knowledge is crucial for identifying any adverse interactions and optimizing combination therapies to ensure patient safety and treatment efficacy. Through this process, researchers can develop a comprehensive understanding of how different drugs interact within the body, guiding clinical decision-making.

Bioanalytical Method Development: Within the domain of bioanalytical method development, Levocetirizine-[d4] emerges as an indispensable component, particularly in methodologies such as liquid chromatography-tandem mass spectrometry (LC-MSMS). Acting as an internal standard, it guarantees the accuracy and precision required for quantifying levocetirizine in complex biological matrices. Method validation using Levocetirizine-[d4] yields reliable and consistent analytical results, crucial for advancing both research endeavors and clinical diagnostics. This method ensures that analytical results are trustworthy and reproducible, providing a solid foundation for further scientific exploration.