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Linaclotide-[d4]

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General Information
Catalog: BLP-004361
Molecular Formula: C59H75D4N15O21S6
Molecular Weight: 1530.76

Chemical Structure

Description	Linaclotide-[d4] is the labelled analogue of a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.
Synonyms	L-Cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-d4-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-tyrosine Cyclic (1→6),(2→10),(5→13)-Tris(disulfide); ((3S,6R,15R,20R,23S,26R,29R,32R,37R,40S,45aS)-32-amino-40-(2-amino-2-oxoethyl)-26-(2-carboxyethyl)-23-(4-hydroxybenzyl)-9-((R)-1-hydroxyethyl)-3-(methyl-d3)-1,4,7,10,13,22,25,28,31,38,41,47-dodecaoxotetracontahydro-19H-37,20-(epiminomethano)-6,29-(methanodithiomethano)pyrrolo[2,1-s][1,2,27,28]tetrathia[5,8,11,14,17,20,23,32,35,38,41]undecaazacyclotritetracontine-15-carbonyl-3-d)-L-tyrosine; Linaclotide D4
Related CAS	851199-59-2 (unlabelled)
Melting Point	>222°C (dec.)
Purity	98% by CP; 99% atom D
Solubility	Slightly soluble in DMSO, Water
Appearance	White to Off-white Solid
Storage	Store at -20°C