| Description |
Losartan-[d4] is the labelled analogue of Losartan. Losartan is the first antagonist (AIIA) of angiotensin II receptor which is a key site in human body that influences blood pressure. |
| Synonyms |
Losartan D4; 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5yl)[1,1'-biphenyl-d4]-4-yl]methyl]-1H-imidazole-5-methanol; Cozaar-d4; MK-954-d4 |
| IUPAC Name |
[2-butyl-5-chloro-3-[[2,3,5,6-tetradeuterio-4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol |
| Related CAS |
114798-26-4 (unlabelled)
|
| Isomeric SMILES |
[2H]C1=C(C(=C(C(=C1CN2C(=NC(=C2CO)Cl)CCCC)[2H])[2H])C3=CC=CC=C3C4=NNN=N4)[2H] |
| Canonical SMILES |
CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl |
| InChI |
InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)/i9D,10D,11D,12D |
| InChI Key |
PSIFNNKUMBGKDQ-IRYCTXJYSA-N |
| Boiling Point |
682.0±65.0 °C at 760 mmHg |
| Melting Point |
128-140°C (dec.) |
| Purity |
95% by HPLC; 95% atom D |
| Density |
1.4±0.1 g/cm3 |
| Solubility |
Soluble in Chloroform, Ethyl Acetate, Methanol |
| Appearance |
White to Off-white Solid |
| Application |
An isotopic labeled form of Losartan which is the first antagonist (AIIA) of angiotensin II receptor which is a key site in human body that influences blood pressure. |
| Shelf Life |
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly |
| Storage |
Store at -20°C |
![Losartan-[d4]](https://resource.bocsci.com/structure/1030937-27-9.gif)
