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Losartan-[d4]

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General Information
Catalog: BLP-012419
CAS: 1030937-27-9
Molecular Formula: C22H19D4ClN6O
Molecular Weight: 426.91

Chemical Structure

Description	Losartan-[d4] is the labelled analogue of Losartan. Losartan is the first antagonist (AIIA) of angiotensin II receptor which is a key site in human body that influences blood pressure.
Synonyms	Losartan D4; 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5yl)[1,1'-biphenyl-d4]-4-yl]methyl]-1H-imidazole-5-methanol; Cozaar-d4; MK-954-d4
IUPAC Name	[2-butyl-5-chloro-3-[[2,3,5,6-tetradeuterio-4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
Related CAS	114798-26-4 (unlabelled)
Isomeric SMILES	[2H]C1=C(C(=C(C(=C1CN2C(=NC(=C2CO)Cl)CCCC)[2H])[2H])C3=CC=CC=C3C4=NNN=N4)[2H]
Canonical SMILES	CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl
InChI	InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)/i9D,10D,11D,12D
InChI Key	PSIFNNKUMBGKDQ-IRYCTXJYSA-N
Boiling Point	682.0±65.0 °C at 760 mmHg
Melting Point	128-140°C (dec.)
Purity	95% by HPLC; 95% atom D
Density	1.4±0.1 g/cm3
Solubility	Soluble in Chloroform, Ethyl Acetate, Methanol
Appearance	White to Off-white Solid
Application	An isotopic labeled form of Losartan which is the first antagonist (AIIA) of angiotensin II receptor which is a key site in human body that influences blood pressure.
Shelf Life	As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Storage	Store at -20°C