CAS 1216745-79-7 Mefenamic Acid-[d4] - Isotope / BOC Sciences

General Information
Catalog: BLP-012813
CAS: 1216745-79-7
Molecular Formula: C15H11D4NO2
Molecular Weight: 245.31

General Information

Catalog: BLP-012813

CAS: 1216745-79-7

Molecular Formula: C15H11D4NO2

Molecular Weight: 245.31

Chemical Structure

Description	Mefenamic Acid-[d4] is the labelled analogue of Mefenamic Acid, which is a competitive inhibitor of COX-1 and COX-2.
Synonyms	Mefenamic Acid D4; N-2,3-Xylylanthranilic-d4 Acid; 2-(2,3-Dimethylanilino)benzoic-d4 Acid; 2-[(2,3-Dimethylphenyl)amino]benzoic-d4 Acid; 2',3'-Dimethyl-N-phenylanthranilic-d4 Acid; Bonabol-d4; Coslan-d4; Lysalgo-d4; Mefacit-d4; Mefenacid-d4; Mefenamic-d4 Acid; Mephenamic-d4 Acid; N-(2,3-Dimethylphenyl)anthranilic-d4 Acid; N-(2,3-Xylyl)-2-aminobenzoic-d4 Acid; NSC 94437-d4; Namphen-d4; Parkemed-d4; Ponalar-d4; Ponstan-d4; Ponstel-d4; Ponstil-d4; Ponstyl-d4; Pontal-d4; Relafan-d4; Tanston-d4; Vialidon-d4
IUPAC Name	2,3,4,5-tetradeuterio-6-(2,3-dimethylanilino)benzoic acid
Related CAS	61-68-7 (unlabelled)
Canonical SMILES	CC1=C(C(=CC=C1)NC2=CC=CC=C2C(=O)O)C
InChI	InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18)/i3D,4D,7D,8D
InChI Key	HYYBABOKPJLUIN-KNIGXJNHSA-N
Melting Point	227-230°C
Purity	98% by HPLC; 98% atom D
Solubility	Soluble in Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Appearance	White to Brown Solid
Storage	Store at -20°C

Mefenamic Acid-[d4], a deuterium-labeled derivative of mefenamic acid, is a commonly utilized nonsteroidal anti-inflammatory drug (NSAID). Here are the key applications of Mefenamic Acid-[d4]:

Pharmacokinetic Studies: Widely employed in pharmacokinetic investigations, Mefenamic Acid-[d4] is utilized to meticulously track and analyze the drug’s absorption, distribution, metabolism, and excretion within the body. Its deuterium labeling enables precise discrimination from the unlabeled compound in mass spectrometry, providing invaluable insights into drug behavior and aiding in the optimization of dosing regimens.

Metabolite Identification: In the realm of drug metabolism research, Mefenamic Acid-[d4] plays a pivotal role in the identification and quantification of metabolites generated during the drug’s processing within the body. The stable isotope labeling offers a stark differentiation from endogenous compounds, facilitating exact metabolite detection. This is critical for the evaluation of drug safety and therapeutic efficacy, ensuring optimal patient outcomes.

Internal Standard in Bioanalytical Assays: Serving as a fundamental internal standard in bioanalytical assays, Mefenamic Acid-[d4] guarantees the precision and reliability of quantitative measurements. By introducing a known quantity of the labeled compound, variances in sample preparation and analysis can be effectively addressed. This enhances the robustness of analytical methods utilized in drug development and clinical trials, bolstering the integrity of research outcomes.

Mechanistic Studies: Applied in mechanistic inquiries, Mefenamic Acid-[d4] is instrumental in exploring the intricate pathways of drug action and its interactions with biological molecules. The labeled compound aids in unraveling complex biochemical processes, offering profound insights into the drug’s mechanisms of action. This understanding is paramount for the development of more efficacious and precisely targeted therapeutic agents, pushing the boundaries of medical advancements.