(±)-Micozole-[d5] Nitrate (2,4-dichlorobenzyloxy-[d5])

(±)-Micozole-[d5] Nitrate (2,4-dichlorobenzyloxy-[d5]) is a deuterated antifungal agent that offers unique applications due to its isotopic labeling. Here are some key applications of (±)-Micozole-[d5] Nitrate:

Clinical Pharmacokinetics: (±)-Micozole-[d5] Nitrate is used in clinical pharmacokinetic studies to track the absorption, distribution, metabolism, and excretion (ADME) of the drug. The deuterium labeling allows for precise measurements using mass spectrometry, facilitating detailed analysis of drug behavior in the body. This information is essential for optimizing dosing regimens and improving therapeutic outcomes.

Metabolic Studies: The deuterated form of miconazole, (±)-Micozole-[d5] Nitrate, is utilized in metabolic pathway studies to investigate the metabolic fate of the drug. It helps researchers identify and quantify metabolites with higher accuracy compared to non-deuterated forms. This aids in understanding the drug’s metabolism and potential interactions with other substances.

Stable Isotope-Labeling: In biochemistry and pharmacology, (±)-Micozole-[d5] Nitrate serves as a stable isotope-labeled compound for tracer studies. Through the use of isotope ratio mass spectrometry (IRMS), researchers can trace the movement and chemical transformations of the compound in biological systems. This application is crucial for elucidating biochemical pathways and drug mechanisms.

Analytical Method Development: (±)-Micozole-[d5] Nitrate is instrumental in developing and validating analytical methods for antifungal drugs. By serving as an internal standard in mass spectrometry assays, it enhances the accuracy and reproducibility of quantification. This application supports the creation of robust and reliable detection methods for clinical and research laboratories.