N-Acetyl-[1-13C]-L-cysteine-[1-13C]

N-Acetyl-[1-13C]-L-cysteine-[1-13C] is a labeled compound commonly used in various scientific research applications. Here are some key applications of N-Acetyl-[1-13C]-L-cysteine-[1-13C]:

Metabolic Tracing: This compound is crucial in metabolic studies to trace biochemical pathways and fluxes. By using N-Acetyl-[1-13C]-L-cysteine-[1-13C], researchers can monitor the incorporation of the labeled carbon atoms through metabolic networks. This helps in understanding the dynamics of cysteine metabolism and other pathways it participates in.

NMR Spectroscopy: The 13C isotopic labeling of N-Acetyl-L-cysteine enhances its utility in nuclear magnetic resonance (NMR) spectroscopy studies. Researchers can utilize 13C NMR to obtain detailed structural and dynamic information about cysteine-containing proteins and peptides. This application is pivotal in elucidating protein folding interactions and conformational changes.

Pharmacokinetic Studies: N-Acetyl-[1-13C]-L-cysteine-[1-13C] can be used in pharmacokinetic and absorption studies to assess the bioavailability and metabolic fate of cysteine-based compounds in vivo. By tracing the labeled compound, researchers gain insights into absorption rates, distribution, metabolism, and excretion. Such data is critical for drug development and therapeutic efficacy evaluations.

Redox Biology Research: In research focused on oxidative stress and redox biology, N-Acetyl-[1-13C]-L-cysteine serves as a tool to study antioxidant mechanisms involving cysteine. The labeled compound allows for precise tracking and analysis of cysteine's role as a precursor to important antioxidants like glutathione. This aids in exploring strategies for managing oxidative stress-related conditions and diseases.