N-acetyl-D-neuraminic acid-[3-13C]

N-acetyl-D-neuraminic acid-[3-13C], a labeled sialic acid extensively utilized in biochemical and medical research, presents a myriad of applications. Here are the key applications:

Glycomics Research: Central to the study of glycoproteins and glycolipids, N-acetyl-D-neuraminic acid-[3-13C] plays a pivotal role in unraveling the intricate structures and functions within various biological systems. By integrating this isotope-labeled sialic acid, researchers delve into comprehensive mass spectrometry analysis, unraveling the enigmatic glycosylation patterns and dynamics. This exploration sheds light on the crucial roles of glycans in diverse realms like cell communication, immunity, and the progression of diseases.

Metabolic Flux Analysis: Within the realm of metabolic studies, N-acetyl-D-neuraminic acid-[3-13C] serves as a vital tracer for unraveling the intricate pathways of sialic acid metabolism within cells. By meticulously monitoring the assimilation and conversion of this labeled compound, scientists glean profound insights into the fluxes and regulatory mechanisms governing sialic acid metabolism. This treasure trove of information is instrumental in unraveling the mysteries of metabolic disorders and laying the foundation for innovative therapeutic interventions.

Drug Development: Positioned at the forefront of pharmaceutical innovation, N-acetyl-D-neuraminic acid-[3-13C] emerges as a cornerstone in drug development endeavors targeting sialic acid-related pathways. Leveraging the capabilities of this labeled compound, researchers embark on precise monitoring and assessment of drug interactions with molecules containing sialic acid. This in-depth scrutiny enhances the comprehension of drug efficacy, pharmacokinetics, and potential side effects, carving a path towards the next frontier of pharmacological discovery.

Pathogen Research: Illuminating the landscape of infectious disease research, N-acetyl-D-neuraminic acid-[3-13C] stands as a critical tool in unraveling the intricate dance between pathogens and host cells. Numerous viruses and bacteria exploit sialic acid residues on the surface of host cells for attachment and invasion. By harnessing the power of this labeled acid, researchers embark on detailed investigations into these intricate interactions, paving the way for the development of targeted antiviral and antibacterial therapies aimed at disrupting these nefarious engagements.