Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-003560 |
CAS: 946524-36-3 |
Molecular Formula: C20H35D4NO2 |
Molecular Weight: 329.55 |
Chemical Structure |
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Description | N-Oleoylethanolamide-[d4], is the labelled analogue of N-Oleoylethanolamide, which is an endogenous agonist for PPARα with an EC50 value of 120 nM in a transactivation assay. |
Synonyms | N-Oleoylethanolamide D4; Oleoyl[1,1,2,2-d4]ethanolamine |
IUPAC Name | (Z)-N-(1,1,2,2-tetradeuterio-2-hydroxyethyl)octadec-9-enamide |
Related CAS | 111-58-0 (unlabelled) |
Isomeric SMILES | [2H]C([2H])(C([2H])([2H])O)NC(=O)CCCCCCC/C=C\CCCCCCCC |
Canonical SMILES | CCCCCCCCC=CCCCCCCCC(=O)NCCO |
InChI | InChI=1S/C20H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h9-10,22H,2-8,11-19H2,1H3,(H,21,23)/b10-9-/i18D2,19D2 |
InChI Key | BOWVQLFMWHZBEF-QAFBOUAWSA-N |
Boiling Point | 496.4±38.0°C at 760 mmHg |
Density | 0.9±0.1 g/cm3 |
N-Oleoylethanolamide-[d4], a stable isotopically-labeled analog of Oleoylethanolamide (OEA), plays a pivotal role in various physiological processes. Here are key applications of N-Oleoylethanolamide-[d4], presented with a high degree of perplexity and burstiness.
Metabolic Research: Delving deep into metabolic intricacies, N-Oleoylethanolamide-[d4] serves as a cornerstone in metabolic studies focusing on lipid metabolism and energy equilibrium. By tracking this labeled compound through biological systems, researchers unravel metabolic pathways and decipher OEA's function in modulating food intake and satiety. This sheds light on combating obesity and metabolic irregularities with innovative treatments.
Receptor Binding Studies: Embarking on a voyage through the realms of neuroscience, N-Oleoylethanolamide-[d4] emerges as a crucial tool for exploring interactions between OEA and its receptor targets. Employing advanced techniques like mass spectrometry, scientists scrutinize binding affinities and receptor activation pathways. This exploration is indispensable in uncovering potential therapeutic avenues for appetite regulation and pain management, opening new vistas for medical interventions.
Pharmacokinetic Studies: At the core of pharmacokinetics lies the indispensable role of this labeled compound in unraveling the absorption, distribution, metabolism, and excretion (ADME) of OEA within the human body. By harnessing N-Oleoylethanolamide-[d4] as a tracer, scientists quantify and scrutinize the biotransformation processes and metabolites of OEA. This methodology aids in refining dosing protocols and assessing drug safety in clinical scenarios, ensuring optimal therapeutic outcomes.
Nutritional Biochemistry: Venturing into the intriguing realm of nutritional biochemistry, N-Oleoylethanolamide-[d4] serves as a linchpin in deciphering the impacts of dietary fats on OEA levels and functions. Researchers leverage this compound to investigate how varied diets influence endogenous OEA production and its implications on body weight and lipid profiles. This research imparts deeper insights into the intricate connections between diet, body weight regulation, and metabolic well-being, paving the way for enhanced understanding of nutrition's impact on overall health.
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