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N- [(S) - (4- Nitrophenoxy) phenoxy- 2,3,4,5,6- d5- phosphinyl] - L- Alanine-[d5] 1- Methylethyl Ester

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General Information
Catalog: BLP-019942
CAS: 1874196-88-9
Molecular Formula: C18H16D5N2O7P
Molecular Weight: 413.37

Chemical Structure

Description	N- [(S) - (4- Nitrophenoxy) phenoxy- 2,3,4,5,6- d5- phosphinyl] - L- Alanine-d5 1- Methylethyl Ester is an intermediate in synthesizing PSI-7977-D5 (P839643), an isotope labelled analog of PSI-7977. PSI-7977 is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
Solubility	Chloroform, Dichloromethane, Ethyl Acetate, Methanol
Appearance	Pale Yellow Oil