Naftifine-[13C,d3] - Isotope / BOC Sciences

General Information
Catalog: BLP-004903
Molecular Formula: C20[13C]H18D3N
Molecular Weight: 291.41

General Information

Catalog: BLP-004903

Molecular Formula: C20[13C]H18D3N

Molecular Weight: 291.41

Chemical Structure

Description	Naftifine-[13C,d3] is the labelled analogue of Naftifine. Naftifine is a topical, synthetic, broad spectrum allylamine derivate. It has antifungal, antibacterial and anti-inflammatory activity and is used for the treatment of tinea pedis, tinea cruris, and tinea corporis.
Synonyms	Naftifine 13CD3; N-Methyl-N-[(2E)-3-phenyl-2-propen-1-yl]-1-naphthalenemethanamine-13C,d3; (E)-Naftifine-13C,d3
IUPAC Name	(E)-N-(naphthalen-1-ylmethyl)-3-phenyl-N-(trideuterio(1-13C)methyl)prop-2-en-1-amine
Related CAS	65472-88-0 (unlabelled)
Canonical SMILES	CN(CC=CC1=CC=CC=C1)CC2=CC=CC3=CC=CC=C32
InChI	InChI=1S/C21H21N/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20/h2-15H,16-17H2,1H3/b11-8+/i1+1D3
InChI Key	OZGNYLLQHRPOBR-QPYZMMTBSA-N
Purity	>98%
Solubility	Slightly soluble in DMSO
Appearance	Pale Yellow to Dark Yellow Thick Oily Matter
Storage	Store at 2-8°C

Naftifine-[13C,d3], an isotopically labeled compound, finds diverse applications in scientific and medical research. Here are key applications of Naftifine-[13C,d3] presented with elevated levels of perplexity and burstiness:

Pharmacokinetic Studies: At the forefront of pharmacokinetic research, Naftifine-[13C,d3] is a pivotal tool for investigating the absorption, distribution, metabolism, and excretion of naftifine within the body. Through the incorporation of isotopic labels, researchers can meticulously track and quantify the compound's journey through biological systems.

Metabolomics Research: In the realm of metabolomics, Naftifine-[13C,d3] assumes the role of an internal standard, facilitating the quantification of metabolites and the exploration of metabolic pathways altered by antifungal treatments. The labeled compound aids in discerning between endogenous metabolites and those originating from naftifine or its isotopic derivative. This application is indispensable for unraveling the drug's influence on cellular metabolism and potential off-target effects, shedding light on its broader biological impact.

Analytical Chemistry: Within the domain of analytical chemistry, Naftifine-[13C,d3] serves as a reference compound for the development and validation of detection methods for naftifine and its metabolites. The isotopic labeling significantly enhances the precision and sensitivity of analytical techniques such as mass spectrometry and nuclear magnetic resonance (NMR). This ensures accurate detection and quantification of naftifine across various sample matrices, including biological fluids and tissues, bolstering the reliability of analytical results.

Toxicological Studies: In the sphere of toxicology, Naftifine-[13C,d3] plays a crucial role in evaluating the safety profile of naftifine and its metabolites, especially in scenarios involving prolonged exposure. The isotopic label enables precise monitoring of the compound's distribution and accumulation in different organs over time. This information is imperative for assessing potential toxicity risks and establishing guidelines for the safe utilization of naftifine-based therapies.