Name: Naftifine-[d3]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-004904

Molecular Formula: C21H18D3N

Molecular Weight: 290.42

Chemical Structure

Description	Naftifine-[d3] is the labelled analogue of Naftifine. Naftifine is a topical, synthetic, broad spectrum allylamine derivate. It has antifungal, antibacterial and anti-inflammatory activity and is used for the treatment of tinea pedis, tinea cruris, and tinea corporis.
Synonyms	Naftifine D3; N-Methyl-N-[(2E)-3-phenyl-2-propen-1-yl]-1-naphthalenemethanamine-d3; (E)-Naftifine-d3
IUPAC Name	(E)-N-(naphthalen-1-ylmethyl)-3-phenyl-N-(trideuteriomethyl)prop-2-en-1-amine
Related CAS	65472-88-0 (unlabelled)
Canonical SMILES	CN(CC=CC1=CC=CC=C1)CC2=CC=CC3=CC=CC=C32
InChI	InChI=1S/C21H21N/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20/h2-15H,16-17H2,1H3/b11-8+/i1D3
InChI Key	OZGNYLLQHRPOBR-VZOBLPKOSA-N
Purity	>98%
Solubility	Slightly soluble in DMSO
Appearance	Pale Yellow to Dark Yellow Thick Oily Matter
Storage	Store at 2-8°C

Naftifine-[d3], a deuterated derivative acclaimed for its potent antifungal properties, finds a myriad of applications in the realm of dermatological fungal infections. Here are key applications of Naftifine-[d3] presented with a high degree of perplexity and burstiness:

Pharmacokinetic Studies: Delving into the intricate realm of pharmacokinetics, Naftifine-[d3] emerges as a pivotal tool for unraveling the absorption, distribution, metabolism, and excretion dynamics of naftifine within the human body. The utilization of deuterium labeling techniques enables meticulous tracking and measurement of naftifine's journey through biological systems, enhancing the precision of data analysis. This nuanced comprehension plays a crucial role in optimizing dosing regimens, ultimately elevating therapeutic outcomes by boosting efficacy to new heights.

Clinical Research: Within the intricate tapestry of clinical research, Naftifine-[d3] shines as a stable isotope-labeled standard essential for fortifying bioanalytical assays. By facilitating the quantitative analysis of naftifine levels in patient samples, it ensures the integrity and reliability of data generated. This indispensable role in clinical trials provides vital pharmacodynamic and pharmacokinetic data, serving as the bedrock for informed decision-making in the development and evaluation of medical approaches.

Drug Interaction Studies: Embarking on the labyrinthine journey of drug interactions, Naftifine-[d3] assumes a central role in unveiling the potential synergies or adverse effects when naftifine interfaces with other drugs. By untangling these intricate interactions, researchers can anticipate and mitigate risks, safeguarding patient well-being and refining treatment protocols with meticulous care.

Metabolic Studies: At the forefront of metabolic investigations, Naftifine-[d3] unravels the complex metabolic pathways and sheds light on the biotransformation of naftifine within hepatic and other tissues. The integration of deuterium in the compound's structure influences its metabolic stability, providing invaluable insights into its destiny within physiological systems. This profound knowledge serves as a cornerstone for crafting novel antifungal agents with optimized pharmacological profiles, paving the way for groundbreaking advancements in therapeutic efficacy and setting new standards for safety in the medical domain.