NeupNAcα2,3[UL-13C6]Galpβ1,3GalpNAc sodium salt

NeupNAc(α2,3)Galpβ1,3GalpNAc-[UL-13C6] sodium salt, a pivotal labeled glycan, has profound significance in diverse biochemical and clinical research realms. Here are the critical applications:

Glycan Analysis: Positioned as a potent tool for profound examination and comprehensive profiling of glycosylation patterns in proteins and lipids, this labeled glycan is instrumental in unraveling intricate glycan structures and compositions using mass spectrometry-based methods. Shedding light on glycan functionalities in health and disease, it enables the exploration of glycan dynamics within the complex web of biological systems.

Therapeutic Glycoengineering: At the forefront of therapeutic glycoengineering, this compound offers a pathway to developing glycoengineered therapeutic proteins with enhanced efficacy and reduced immunogenicity. By integrating specific glycan structures, researchers can refine therapeutic proteins to boost pharmacokinetic profiles and biological potency, fostering versatility in sculpting glycosylation patterns in biologic drug innovation.

Cellular Glycomics: Embraced in cellular glycomics inquiries, this glycan illuminates the intricate world of cell-cell interactions, signaling cascades, and cellular responses regulated by glycosylation phenomena. By labeling cell surface glycans with NeupNAc(α2,3)Galpβ1,3GalpNAc-[UL-13C6] sodium salt, researchers glean insights into fluctuations in glycan expression under diverse conditions, a critical stepping stone for unraveling the nuanced roles of glycans in cellular biology and the underlying mechanisms of diseases.