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NG,NG-Dimethyl-[d6]-L-arginine dihydrochloride

General Information
Catalog: BLP-009741
Molecular Formula: C8D6H14Cl2N4O2
Molecular Weight: 281.21
Chemical Structure
NG,NG-Dimethyl-[d6]-L-arginine dihydrochloride
Description NG,NG-Dimethyl-[d6]-L-arginine dihydrochloride is a labelled NG,NG-Dimethyl-L-arginine dihydrochloride, which is an endogenous nitric oxide synthase inhibitor.
Synonyms asym-Dimethyl-d6-arginine; ADMA-d6
IUPAC Name (2S)-2-amino-5-[[amino-[bis(trideuteriomethyl)amino]methylidene]amino]pentanoic acid;dihydrochloride
Related CAS 20805-22-1 (unlabelled)
Canonical SMILES CN(C)C(=NCCCC(C(=O)O)N)N.Cl.Cl
InChI InChI=1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1/i1D3,2D3;;
InChI Key SYLNVYJOPZWPJI-WTPXGJEESA-N
Melting Point −20°C
Purity 95% by HPLC; 99% atom D
Storage Store at −20°C

NG,NG-Dimethyl-[d6]-L-arginine dihydrochloride, a stable isotopically-labeled compound utilized in biochemical research, serves a multitude of purposes. Here are key applications presented with high perplexity and burstiness:

Mass Spectrometry: Positioned as a fundamental internal standard in the realm of mass spectrometry analyses, this compound assumes a pivotal role. Its stable isotopic label not only enables the precise quantification of L-arginine-related metabolites within intricately woven biological samples but also establishes a robust reference point, ensuring the reliability and consistency of analytical measurements.

Protein Methylation Studies: Diving deep into the labyrinth of protein methylation processes and unveiling the profound significance of dimethylated arginine residues in biological contexts, researchers turn their gaze towards NG,NG-Dimethyl-[d6]-L-arginine dihydrochloride. By seamlessly integrating this labeled compound into proteins, they embark on a journey to meticulously track and measure methylation dynamics, shedding light on regulatory mechanisms and uncovering potential therapeutic targets in diseases intricately shaped by arginine methylation.

Nutritional Research: In the expansive domain of nutritional science, this compound emerges as a beacon of invaluable insight, guiding researchers in tracing and evaluating the metabolic destiny of arginine in human and animal studies. Leveraging the power of the isotopic label, scientists plunge into the intricate transformation of arginine into nitric oxide and other metabolites, crucial for unraveling arginine's pivotal role in cardiovascular health and its sprawling impact on metabolism.

Pharmacokinetics: Within the intricate web of pharmacokinetic investigations, researchers harness the power of NG,NG-Dimethyl-[d6]-L-arginine dihydrochloride to meticulously monitor the absorption, distribution, metabolism, and excretion of arginine-associated compounds. The isotopic label serves as a beacon of clarity, aiding in the discrimination between administered compounds and endogenous arginine, thereby offering profound insights into drug behavior and facilitating the fine-tuning of dosing regimens within therapeutic contexts.

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