CAS 1795140-41-8 Nomifensine-[d3] Maleic Acid Salt

General Information
Catalog: BLP-003562
CAS: 1795140-41-8
Molecular Formula: C20H19D3N2O4
Molecular Weight: 357.42

General Information

Catalog: BLP-003562

CAS: 1795140-41-8

Molecular Formula: C20H19D3N2O4

Molecular Weight: 357.42

Chemical Structure

Description	Nomifensine-[d3] Maleic Acid Salt, is the labelled analogue of Nomifensine. Nomifensine is a norepinephrine-dopamine reuptake inhibitor.
Synonyms	Nomifensine-d3 Maleic Acid Salt
IUPAC Name	(Z)-but-2-enedioic acid;4-phenyl-2-(trideuteriomethyl)-3,4-dihydro-1H-isoquinolin-8-amine
Related CAS	32795-47-4 (unlabelled) 1216750-73-0 (free base)
Canonical SMILES	CN1CC(C2=C(C1)C(=CC=C2)N)C3=CC=CC=C3.C(=CC(=O)O)C(=O)O
InChI	InChI=1S/C16H18N2.C4H4O4/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18;5-3(6)1-2-4(7)8/h2-9,14H,10-11,17H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/i1D3;
InChI Key	GEOCVSMCLVIOEV-REHQRYIOSA-N
Melting Point	>186°C(dec.)
Solubility	Soluble in DMSO, Methanol
Appearance	Off-white to Pale Yellow Solid
Storage	Store at-20°C, Under inert atmosphere

Nomifensine-[d3] Maleic Acid Salt, a deuterium-labeled derivative of Nomifensine, finds primary application in research settings. Here are key applications presented with high perplexity and burstiness.

Pharmacokinetic Studies: Employing Nomifensine-[d3] Maleic Acid Salt in pharmacokinetic investigations unlocks insights into the absorption, distribution, metabolism, and excretion of Nomifensine within the body. This deuterated form acts as a stable isotope tracer, enabling researchers to discern between the drug and its metabolites in biological samples. The knowledge gained from such studies plays a pivotal role in optimizing dosing regimens and elevating drug effectiveness.

Metabolomics: Within the realm of metabolomics, Nomifensine-[d3] Maleic Acid Salt serves as a crucial internal standard for quantifying Nomifensine and associated compounds within intricate biological matrices. With its stable isotope labeling, this compound facilitates precise and reliable mass spectrometric analysis, essential for uncovering metabolic shifts and exploring biomarker discovery. This application proves especially valuable in deciphering disease states and evaluating therapeutic responses.

Neurochemical Research: Nomifensine-[d3] Maleic Acid Salt emerges as a fundamental instrument in neurochemical inquiries that delve into dopamine uptake and neurotransmitter systems. By leveraging this deuterium-labeled compound, researchers can gauge the impact of Nomifensine on the central nervous system with heightened accuracy. Such studies play a pivotal role in enhancing understanding of neurological disorders and guiding the development of novel interventions.

Drug Development: In the domain of drug development research, Nomifensine-[d3] Maleic Acid Salt assumes a critical role in assessing the interactions and stability of Nomifensine across diverse conditions. Its utilization in preclinical evaluations aids in gauging pharmacological profiles and potential drug-drug interactions. These insights serve as linchpins in the creation of safer and more efficacious pharmaceutical formulations, driving innovation in the realm of drug development.